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Design and self-assembly of two-dimensional DNA crystals

Author

Listed:
  • Erik Winfree

    (Computation and Neural Systems, California Institute of Technology)

  • Furong Liu

    (New York University, New York)

  • Lisa A. Wenzler

    (New York University, New York)

  • Nadrian C. Seeman

    (New York University, New York)

Abstract

Molecular self-assembly presents a ‘bottom-up’ approach to the fabrication of objects specified with nanometre precision. DNA molecular structures and intermolecular interactions are particularly amenable to the design and synthesis of complex molecular objects. We report the design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules. Intermolecular interactions between the structural units are programmed by the design of ‘sticky ends’ that associate according to Watson–Crick complementarity, enabling us to create specific periodic patterns on the nanometre scale. The patterned crystals have been visualized by atomic force microscopy.

Suggested Citation

  • Erik Winfree & Furong Liu & Lisa A. Wenzler & Nadrian C. Seeman, 1998. "Design and self-assembly of two-dimensional DNA crystals," Nature, Nature, vol. 394(6693), pages 539-544, August.
    • Handle: RePEc:nat:nature:v:394:y:1998:i:6693:d:10.1038_28998
    DOI: 10.1038/28998
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    Citations

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    Cited by:

    1. Omar A. Saleh & Sam Wilken & Todd M. Squires & Tim Liedl, 2023. "Vacuole dynamics and popping-based motility in liquid droplets of DNA," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    2. Kumar S. Ray & Mandrita Mondal, 2016. "Logical Inference by DNA Strand Algebra," New Mathematics and Natural Computation (NMNC), World Scientific Publishing Co. Pte. Ltd., vol. 12(01), pages 29-44, March.
    3. Wang, Liqiu & Zhang, Yuxiang & Cheng, Lin, 2009. "Magic microfluidic T-junctions: Valving and bubbling," Chaos, Solitons & Fractals, Elsevier, vol. 39(4), pages 1530-1537.
    4. Wenqing Xu & Guanheng Huang & Zhan Yang & Ziqi Deng & Chen Zhou & Jian-An Li & Ming-De Li & Tao Hu & Ben Zhong Tang & David Lee Phillips, 2024. "Nucleic-acid-base photofunctional cocrystal for information security and antimicrobial applications," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    5. Daniela Sorrentino & Simona Ranallo & Francesco Ricci & Elisa Franco, 2024. "Developmental assembly of multi-component polymer systems through interconnected synthetic gene networks in vitro," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Sungwook Woo & Sinem K. Saka & Feng Xuan & Peng Yin, 2024. "Molecular robotic agents that survey molecular landscapes for information retrieval," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    7. Xiang Tian & Xiyu Liu & Hongyan Zhang & Minghe Sun & Yuzhen Zhao, 2020. "A DNA algorithm for the job shop scheduling problem based on the Adleman-Lipton model," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-21, December.
    8. Aleck Johnsen & Ming-Yang Kao & Shinnosuke Seki, 2017. "A manually-checkable proof for the NP-hardness of 11-color pattern self-assembly tileset synthesis," Journal of Combinatorial Optimization, Springer, vol. 33(2), pages 496-529, February.
    9. Tyler G Moore & Max H Garzon & Russell J Deaton, 2015. "Probabilistic Analysis of Pattern Formation in Monotonic Self-Assembly," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-23, September.
    10. Shivendra Pandey & Daniel Johnson & Ryan Kaplan & Joseph Klobusicky & Govind Menon & David H Gracias, 2014. "Self-Assembly of Mesoscale Isomers: The Role of Pathways and Degrees of Freedom," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-7, October.

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