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Structural, molecular and developmental evidence for cell-type diversity in cnidarian mechanosensory neurons

Author

Listed:
  • Julia Baranyk

    (University of Arkansas)

  • Kristen Malir

    (University of Arkansas)

  • Miguel A. P. Silva

    (University of Arkansas
    University of Lisbon)

  • Sakura Rieck

    (University of Arkansas)

  • Gracie Scheve

    (Bowdoin College)

  • Nagayasu Nakanishi

    (University of Arkansas)

Abstract

Deploying a conserved mechanosensory neuron known as the concentric hair cell, cnidarians have evolved diverse mechanoreceptors from hydroid filiform tentacles to jellyfish statocysts. However, it is unknown whether cnidarian mechanoreceptor evolution has relied solely on repurposing a single ancestral mechanosensory neuron type. Here we report evidence for cell-type diversity of mechanosensory neurons in sea-anemone cnidarian Nematostella vectensis. Uncovered in the ectoderm of feeding tentacles are conventional type I hair cells and previously unrecognized type II hair cells differing in the structure of apical sensory apparatus and synapses. Moreover, we identify TRP channel-encoding gene polycystin-1 as a type-II-hair-cell-specific essential mediator of gentle touch response. Ontogenically, type I and type II hair cells derive from distinct postmitotic precursors that begin forming at different phases of larval development. Taken together, our findings suggest that anatomically, molecularly, and developmentally distinct mechanosensory neurons diversified within Cnidaria, or prior to the divergence of Cnidaria and Bilateria.

Suggested Citation

  • Julia Baranyk & Kristen Malir & Miguel A. P. Silva & Sakura Rieck & Gracie Scheve & Nagayasu Nakanishi, 2025. "Structural, molecular and developmental evidence for cell-type diversity in cnidarian mechanosensory neurons," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56115-2
    DOI: 10.1038/s41467-025-56115-2
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    References listed on IDEAS

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    1. Aissam Ikmi & Sean A. McKinney & Kym M. Delventhal & Matthew C. Gibson, 2014. "TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    2. Darrin T. Schultz & Steven H. D. Haddock & Jessen V. Bredeson & Richard E. Green & Oleg Simakov & Daniel S. Rokhsar, 2023. "Ancient gene linkages support ctenophores as sister to other animals," Nature, Nature, vol. 618(7963), pages 110-117, June.
    3. Bob Zimmermann & Juan D. Montenegro & Sofia M. C. Robb & Whitney J. Fropf & Lukas Weilguny & Shuonan He & Shiyuan Chen & Jessica Lovegrove-Walsh & Eric M. Hill & Cheng-Yi Chen & Katerina Ragkousi & Da, 2023. "Topological structures and syntenic conservation in sea anemone genomes," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Wei Li & Lijun Kang & Beverly J. Piggott & Zhaoyang Feng & X.Z. Shawn Xu, 2011. "The neural circuits and sensory channels mediating harsh touch sensation in Caenorhabditis elegans," Nature Communications, Nature, vol. 2(1), pages 1-9, September.
    5. Mansi Srivastava & Emina Begovic & Jarrod Chapman & Nicholas H. Putnam & Uffe Hellsten & Takeshi Kawashima & Alan Kuo & Therese Mitros & Asaf Salamov & Meredith L. Carpenter & Ana Y. Signorovitch & Ma, 2008. "The Trichoplax genome and the nature of placozoans," Nature, Nature, vol. 454(7207), pages 955-960, August.
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