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mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae

Author

Listed:
  • Brady Dolan

    (Yale University School of Medicine)

  • Tomás Correa Gaviria

    (Yale University School of Medicine)

  • Yuemei Dong

    (Johns Hopkins University)

  • Peter Cresswell

    (Yale University School of Medicine)

  • George Dimopoulos

    (Johns Hopkins University)

  • Yu-Min Chuang

    (Yale University School of Medicine)

  • Erol Fikrig

    (Yale University School of Medicine)

Abstract

Plasmodium, the causative agents of malaria, are obtained by mosquitoes from an infected human. Following Plasmodium acquisition by Anopheles gambiae, mosquito gamma-interferon-inducible lysosomal thiol reductase (mosGILT) plays a critical role in its subsequent sporogony in the mosquito. A critical location for this development is the midgut, a tissue we show expresses mosGILT. Using membrane-feeding and murine infection models, we demonstrate that antibodies against mosGILT reduce the number of P. falciparum and P. berghei oocysts in the midgut and the infection prevalence of both species in the mosquito. mosGILT antibodies act in the mosquito midgut, specifically impacting the Plasmodium oocyst stage. Targeting mosGILT can therefore interfere with the Plasmodium life cycle in the mosquito and potentially serve as a transmission-blocking vaccine.

Suggested Citation

  • Brady Dolan & Tomás Correa Gaviria & Yuemei Dong & Peter Cresswell & George Dimopoulos & Yu-Min Chuang & Erol Fikrig, 2025. "mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-55902-1
    DOI: 10.1038/s41467-025-55902-1
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