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A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission

Author

Listed:
  • Tyler R. Schleicher

    (Yale University School of Medicine)

  • Jing Yang

    (Yale University School of Medicine)

  • Marianna Freudzon

    (Yale University School of Medicine)

  • Alison Rembisz

    (Yale University School of Medicine)

  • Samuel Craft

    (Yale University School of Medicine)

  • Madeleine Hamilton

    (Yale University School of Medicine)

  • Morven Graham

    (Yale University School of Medicine)

  • Godfree Mlambo

    (Johns Hopkins University)

  • Abhai K. Tripathi

    (Johns Hopkins University)

  • Yue Li

    (Yale University School of Medicine)

  • Peter Cresswell

    (Yale University School of Medicine)

  • Photini Sinnis

    (Johns Hopkins University)

  • George Dimopoulos

    (Johns Hopkins University)

  • Erol Fikrig

    (Yale University School of Medicine
    Howard Hughes Medical Institute)

Abstract

The key step during the initiation of malaria is for motile Plasmodium parasites to exit the host dermis and infect the liver. During transmission, the parasites in the form of sporozoites, are injected together with mosquito saliva into the skin. However, the contribution of vector saliva to sporozoite activity during the establishment of the initial infection of the liver is poorly understood. Here we identify a vector protein by mass spectrometry, with similarity to the human gamma interferon inducible thiol reductase (GILT), that is associated with saliva sporozoites of infected Anopheles mosquitoes and has a negative impact on the speed and cell traversal activity of Plasmodium. This protein, referred to as mosquito GILT (mosGILT) represents an example of a protein found in mosquito saliva that may negatively influence sporozoite movement in the host and could lead to new approaches to prevent malaria.

Suggested Citation

  • Tyler R. Schleicher & Jing Yang & Marianna Freudzon & Alison Rembisz & Samuel Craft & Madeleine Hamilton & Morven Graham & Godfree Mlambo & Abhai K. Tripathi & Yue Li & Peter Cresswell & Photini Sinni, 2018. "A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-05374-3
    DOI: 10.1038/s41467-018-05374-3
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    Cited by:

    1. Zarna Rajeshkumar Pala & Thiago Luiz Alves e Silva & Mahnaz Minai & Benjamin Crews & Eduardo Patino-Martinez & Carmelo Carmona-Rivera & Paola Carolina Valenzuela Leon & Ines Martin-Martin & Yevel Flor, 2024. "Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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