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Mapping bacterial extracellular vesicle research: insights, best practices and knowledge gaps

Author

Listed:
  • Nele De Langhe

    (Ghent University
    Cancer Research Institute Ghent
    Ghent University
    Ghent University Hospital)

  • Sofie Van Dorpe

    (Ghent University
    Cancer Research Institute Ghent
    Ghent University Hospital)

  • Niké Guilbert

    (Ghent University
    Cancer Research Institute Ghent)

  • Amélie Vander Cruyssen

    (Ghent University
    Cancer Research Institute Ghent)

  • Quentin Roux

    (Ghent University
    Cancer Research Institute Ghent
    INSERM, CNRS)

  • Sarah Deville

    (Ghent University
    Cancer Research Institute Ghent
    Jessa Hospital)

  • Sándor Dedeyne

    (Ghent University
    Cancer Research Institute Ghent)

  • Philippe Tummers

    (Ghent University Hospital)

  • Hannelore Denys

    (Cancer Research Institute Ghent
    Ghent University Hospital)

  • Linos Vandekerckhove

    (Ghent University
    Ghent University Hospital)

  • Olivier De Wever

    (Ghent University
    Cancer Research Institute Ghent)

  • An Hendrix

    (Ghent University
    Cancer Research Institute Ghent)

Abstract

Bacterial extracellular vesicles (BEVs) enable communication between bacteria and their natural habitats, including multicellular organisms such as humans. Consequently, the study of BEVs has rapidly gained attention with recent research raising the prospect of developing BEVs as biomarkers and treatments to manage (mal)functioning of natural habitats. Although diverse technologies are available, the composition of their source, their heterogeneity in biophysical and biochemical features, and their multifaceted cargo composition challenges the analysis of BEVs. To map current practices in BEV research, we analyzed 845 publications released in 2015–2021, reporting 3338 BEV-related experiments. The extracted data are accessible via the publicly available EV-TRACK knowledgebase ( https://evtrack.org/ ). We identify the need for transparent reporting, delineate knowledge gaps, outline available best practices and define areas in need of guidance to ensure advances in BEV research and accelerate BEV applications.

Suggested Citation

  • Nele De Langhe & Sofie Van Dorpe & Niké Guilbert & Amélie Vander Cruyssen & Quentin Roux & Sarah Deville & Sándor Dedeyne & Philippe Tummers & Hannelore Denys & Linos Vandekerckhove & Olivier De Wever, 2024. "Mapping bacterial extracellular vesicle research: insights, best practices and knowledge gaps," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53279-1
    DOI: 10.1038/s41467-024-53279-1
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    References listed on IDEAS

    as
    1. Rogers A. Ñahui Palomino & Christophe Vanpouille & Luca Laghi & Carola Parolin & Kamran Melikov & Peter Backlund & Beatrice Vitali & Leonid Margolis, 2019. "Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    2. Oh Youn Kim & Hyun Taek Park & Nhung Thi Hong Dinh & Seng Jin Choi & Jaewook Lee & Ji Hyun Kim & Seung-Woo Lee & Yong Song Gho, 2017. "Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    3. Xiaogang Wang & Christopher D. Thompson & Christopher Weidenmaier & Jean C. Lee, 2018. "Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
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