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Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

Author

Listed:
  • Oh Youn Kim

    (Pohang University of Science and Technology)

  • Hyun Taek Park

    (Pohang University of Science and Technology)

  • Nhung Thi Hong Dinh

    (Pohang University of Science and Technology)

  • Seng Jin Choi

    (Pohang University of Science and Technology)

  • Jaewook Lee

    (Pohang University of Science and Technology)

  • Ji Hyun Kim

    (Pohang University of Science and Technology)

  • Seung-Woo Lee

    (Pohang University of Science and Technology)

  • Yong Song Gho

    (Pohang University of Science and Technology)

Abstract

Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with outer membrane proteins, to the surroundings. Outer membrane vesicles have gained wide interests as non-living complex vaccines or delivery vehicles. However, no study has used outer membrane vesicles in treating cancer thus far. Here we investigate the potential of bacterial outer membrane vesicles as therapeutic agents to treat cancer via immunotherapy. Our results show remarkable capability of bacterial outer membrane vesicles to effectively induce long-term antitumor immune responses that can fully eradicate established tumors without notable adverse effects. Moreover, systematically administered bacterial outer membrane vesicles specifically target and accumulate in the tumor tissue, and subsequently induce the production of antitumor cytokines CXCL10 and interferon-γ. This antitumor effect is interferon-γ dependent, as interferon-γ-deficient mice could not induce such outer membrane vesicle-mediated immune response. Together, our results herein demonstrate the potential of bacterial outer membrane vesicles as effective immunotherapeutic agent that can treat various cancers without apparent adverse effects.

Suggested Citation

  • Oh Youn Kim & Hyun Taek Park & Nhung Thi Hong Dinh & Seng Jin Choi & Jaewook Lee & Ji Hyun Kim & Seung-Woo Lee & Yong Song Gho, 2017. "Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00729-8
    DOI: 10.1038/s41467-017-00729-8
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    Cited by:

    1. Nele De Langhe & Sofie Van Dorpe & Niké Guilbert & Amélie Vander Cruyssen & Quentin Roux & Sarah Deville & Sándor Dedeyne & Philippe Tummers & Hannelore Denys & Linos Vandekerckhove & Olivier De Wever, 2024. "Mapping bacterial extracellular vesicle research: insights, best practices and knowledge gaps," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Wan-Ru Zhuang & Yunfeng Wang & Weidong Nie & Yao Lei & Chao Liang & Jiaqi He & Liping Zuo & Li-Li Huang & Hai-Yan Xie, 2023. "Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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