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Pre-bilaterian origin of the blastoporal axial organizer

Author

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  • Yulia Kraus

    (Centre of Organismal Systems Biology, University of Vienna
    Biological Faculty, Moscow State University)

  • Andy Aman

    (Centre of Organismal Systems Biology, University of Vienna)

  • Ulrich Technau

    (Centre of Organismal Systems Biology, University of Vienna)

  • Grigory Genikhovich

    (Centre of Organismal Systems Biology, University of Vienna)

Abstract

The startling capacity of the amphibian Spemann organizer to induce naïve cells to form a Siamese twin embryo with a second set of body axes is one of the hallmarks of developmental biology. However, the axis-inducing potential of the blastopore-associated tissue is commonly regarded as a chordate feature. Here we show that the blastopore lip of a non-bilaterian metazoan, the anthozoan cnidarian Nematostella vectensis, possesses the same capacity and uses the same molecular mechanism for inducing extra axes as chordates: Wnt/β-catenin signaling. We also demonstrate that the establishment of the secondary, directive axis in Nematostella by BMP signaling is sensitive to an initial Wnt signal, but once established the directive axis becomes Wnt-independent. By combining molecular analysis with experimental embryology, we provide evidence that the emergence of the Wnt/β-catenin driven blastopore-associated axial organizer predated the cnidarian-bilaterian split over 600 million years ago.

Suggested Citation

  • Yulia Kraus & Andy Aman & Ulrich Technau & Grigory Genikhovich, 2016. "Pre-bilaterian origin of the blastoporal axial organizer," Nature Communications, Nature, vol. 7(1), pages 1-9, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11694
    DOI: 10.1038/ncomms11694
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    Cited by:

    1. Paula Miramón-Puértolas & Eudald Pascual-Carreras & Patrick R. H. Steinmetz, 2024. "A population of Vasa2 and Piwi1 expressing cells generates germ cells and neurons in a sea anemone," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Alison G. Cole & Stefan M. Jahnel & Sabrina Kaul & Julia Steger & Julia Hagauer & Andreas Denner & Patricio Ferrer Murguia & Elisabeth Taudes & Bob Zimmermann & Robert Reischl & Patrick R. H. Steinmet, 2023. "Muscle cell-type diversification is driven by bHLH transcription factor expansion and extensive effector gene duplications," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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