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Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

Author

Listed:
  • Shahram Bahrami

    (University of Oslo)

  • Kaja Nordengen

    (University of Oslo
    Oslo University Hospital)

  • Alexey A. Shadrin

    (University of Oslo
    University of Oslo)

  • Oleksandr Frei

    (University of Oslo
    University of Oslo)

  • Dennis Meer

    (University of Oslo
    Maastricht University)

  • Anders M. Dale

    (University of California
    University of California San Diego
    University of California at San Diego)

  • Lars T. Westlye

    (University of Oslo
    University of Oslo
    University of Oslo)

  • Ole A. Andreassen

    (University of Oslo
    University of Oslo)

  • Tobias Kaufmann

    (University of Oslo
    University of Tübingen)

Abstract

Despite its major role in complex human functions across the lifespan, most notably navigation, learning and memory, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 white British individuals, we reveal 177 unique genetic loci with distributed associations across the hippocampal formation. We identify genetic overlap with eight brain disorders with typical onset at different stages of life, where common genes suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.

Suggested Citation

  • Shahram Bahrami & Kaja Nordengen & Alexey A. Shadrin & Oleksandr Frei & Dennis Meer & Anders M. Dale & Lars T. Westlye & Ole A. Andreassen & Tobias Kaufmann, 2022. "Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31086-w
    DOI: 10.1038/s41467-022-31086-w
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    References listed on IDEAS

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