IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-15948-9.html
   My bibliography  Save this article

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

Author

Listed:
  • Thomas J. Littlejohns

    (University of Oxford)

  • Jo Holliday

    (University of Oxford)

  • Lorna M. Gibson

    (University of Edinburgh
    New Royal Infirmary of Edinburgh)

  • Steve Garratt

    (UK Biobank Coordinating Centre)

  • Niels Oesingmann

    (UK Biobank Coordinating Centre)

  • Fidel Alfaro-Almagro

    (University of Oxford)

  • Jimmy D. Bell

    (University of Westminster)

  • Chris Boultwood

    (UK Biobank Coordinating Centre)

  • Rory Collins

    (University of Oxford)

  • Megan C. Conroy

    (University of Oxford)

  • Nicola Crabtree

    (Birmingham Women’s and Children’s NHS Foundation Trust)

  • Nicola Doherty

    (UK Biobank Coordinating Centre)

  • Alejandro F. Frangi

    (Department of Cardiovascular Sciences and Electrical Engineering, KU Leuven
    University of Leeds)

  • Nicholas C. Harvey

    (University of Southampton)

  • Paul Leeson

    (University of Oxford)

  • Karla L. Miller

    (University of Oxford)

  • Stefan Neubauer

    (University of Oxford)

  • Steffen E. Petersen

    (Queen Mary University of Medicine)

  • Jonathan Sellors

    (University of Oxford
    UK Biobank Coordinating Centre)

  • Simon Sheard

    (UK Biobank Coordinating Centre)

  • Stephen M. Smith

    (University of Oxford)

  • Cathie L. M. Sudlow

    (University of Edinburgh)

  • Paul M. Matthews

    (Imperial College London and UK Dementia Research Institute)

  • Naomi E. Allen

    (University of Oxford)

Abstract

UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.

Suggested Citation

  • Thomas J. Littlejohns & Jo Holliday & Lorna M. Gibson & Steve Garratt & Niels Oesingmann & Fidel Alfaro-Almagro & Jimmy D. Bell & Chris Boultwood & Rory Collins & Megan C. Conroy & Nicola Crabtree & N, 2020. "The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15948-9
    DOI: 10.1038/s41467-020-15948-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-15948-9
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-020-15948-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Bingxin Zhao & Yujue Li & Zirui Fan & Zhenyi Wu & Juan Shu & Xiaochen Yang & Yilin Yang & Xifeng Wang & Bingxuan Li & Xiyao Wang & Carlos Copana & Yue Yang & Jinjie Lin & Yun Li & Jason L. Stein & Joa, 2024. "Eye-brain connections revealed by multimodal retinal and brain imaging genetics," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Andrea I. Luppi & Helena M. Gellersen & Zhen-Qi Liu & Alexander R. D. Peattie & Anne E. Manktelow & Ram Adapa & Adrian M. Owen & Lorina Naci & David K. Menon & Stavros I. Dimitriadis & Emmanuel A. Sta, 2024. "Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    3. Saaket Agrawal & Marcus D. R. Klarqvist & Nathaniel Diamant & Takara L. Stanley & Patrick T. Ellinor & Nehal N. Mehta & Anthony Philippakis & Kenney Ng & Melina Claussnitzer & Steven K. Grinspoon & Pu, 2023. "BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Catherine M. Francis & Matthias E. Futschik & Jian Huang & Wenjia Bai & Muralidharan Sargurupremraj & Alexander Teumer & Monique M. B. Breteler & Enrico Petretto & Amanda S. R. Ho & Philippe Amouyel &, 2022. "Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Kung, Claryn S.J. & Pudney, Stephen E. & Shields, Michael A., 2022. "Economic gradients in loneliness, social isolation and social support: Evidence from the UK Biobank," Social Science & Medicine, Elsevier, vol. 306(C).
    6. Parsa Akbari & Olukayode A. Sosina & Jonas Bovijn & Karl Landheer & Jonas B. Nielsen & Minhee Kim & Senem Aykul & Tanima De & Mary E. Haas & George Hindy & Nan Lin & Ian R. Dinsmore & Jonathan Z. Luo , 2022. "Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    7. Celeste McCracken & Zahra Raisi-Estabragh & Michele Veldsman & Betty Raman & Andrea Dennis & Masud Husain & Thomas E. Nichols & Steffen E. Petersen & Stefan Neubauer, 2022. "Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    8. Saaket Agrawal & Minxian Wang & Marcus D. R. Klarqvist & Kirk Smith & Joseph Shin & Hesam Dashti & Nathaniel Diamant & Seung Hoan Choi & Sean J. Jurgens & Patrick T. Ellinor & Anthony Philippakis & Me, 2022. "Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15948-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.