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Glutathione peroxidase 3 is a potential biomarker for konzo

Author

Listed:
  • Matthew S. Bramble

    (Children’s National Hospital
    The George Washington University of Medicine and Health Sciences)

  • Victor Fourcassié

    (CHU de Québec - Université Laval Research Center)

  • Neerja Vashist

    (UCLA)

  • Florence Roux-Dalvai

    (CHU de Québec - Université Laval Research Center)

  • Yun Zhou

    (Children’s National Hospital)

  • Guy Bumoko

    (Kinshasa University)

  • Michel Lupamba Kasendue

    (Institut National de Recherche Biomédicale (INRB))

  • D’Andre Spencer

    (Children’s National Hospital)

  • Hilaire Musasa Hanshi-Hatuhu

    (Kinshasa University
    Institut National de Recherche Biomédicale (INRB))

  • Vincent Kambale-Mastaki

    (Institut National de Recherche Biomédicale (INRB))

  • Rafael Vincent M. Manalo

    (University of the Philippines, Manila, Ermita)

  • Aliyah Mohammed

    (Children’s National Hospital)

  • David R. McIlwain

    (University of Nevada, Reno School of Medicine)

  • Gary Cunningham

    (Children’s National Hospital)

  • Marshall Summar

    (Children’s National Hospital)

  • Michael J. Boivin

    (Michigan State University)

  • Ljubica Caldovic

    (Children’s National Hospital
    The George Washington University of Medicine and Health Sciences)

  • Eric Vilain

    (University of California)

  • Dieudonne Mumba-Ngoyi

    (Institut National de Recherche Biomédicale (INRB))

  • Desire Tshala-Katumbay

    (Institut National de Recherche Biomédicale (INRB)
    Oregon Health & Science University)

  • Arnaud Droit

    (CHU de Québec - Université Laval Research Center)

Abstract

Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the world’s poorest children and women of childbearing ages across regions of sub-Saharan Africa. Despite understanding the dietary factors that lead to konzo, the molecular markers and mechanisms that trigger this disease remain unknown. To identify potential protein biomarkers associated with a disease status, plasma was collected from two independent Congolese cohorts, a discovery cohort (n = 60) and validation cohort (n = 204), sampled 10 years apart and subjected to multiple high-throughput assays. We identified that Glutathione Peroxidase 3 (GPx3), a critical plasma-based antioxidant enzyme, was the sole protein examined that was both significantly and differentially abundant between affected and non-affected participants in both cohorts, with large reductions observed in those affected with konzo. Our findings raise the notion that reductions in key antioxidant mechanisms may be the biological risk factor for the development of konzo, particularly those mediated through pathways involving the glutathione peroxidase family.

Suggested Citation

  • Matthew S. Bramble & Victor Fourcassié & Neerja Vashist & Florence Roux-Dalvai & Yun Zhou & Guy Bumoko & Michel Lupamba Kasendue & D’Andre Spencer & Hilaire Musasa Hanshi-Hatuhu & Vincent Kambale-Mast, 2024. "Glutathione peroxidase 3 is a potential biomarker for konzo," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52136-5
    DOI: 10.1038/s41467-024-52136-5
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    References listed on IDEAS

    as
    1. Matthew S. Bramble & Neerja Vashist & Arthur Ko & Sambhawa Priya & Céleste Musasa & Alban Mathieu & D’ Andre Spencer & Michel Lupamba Kasendue & Patrick Mamona Dilufwasayo & Kevin Karume & Joanna Nsib, 2021. "The gut microbiome in konzo," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Florian Rohart & Benoît Gautier & Amrit Singh & Kim-Anh Lê Cao, 2017. "mixOmics: An R package for ‘omics feature selection and multiple data integration," PLOS Computational Biology, Public Library of Science, vol. 13(11), pages 1-19, November.
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