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NAD+ deficiency primes defense metabolism via 1O2-escalated jasmonate biosynthesis in plants

Author

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  • Yechun Hong

    (Southern University of Science and Technology
    Southern University of Science and Technology)

  • Zongjun Yu

    (Southern University of Science and Technology)

  • Qian Zhou

    (Southern University of Science and Technology)

  • Chunyu Chen

    (Southern University of Science and Technology)

  • Yuqiong Hao

    (Southern University of Science and Technology
    Shanxi Agricultural University)

  • Zhen Wang

    (Anhui Agricultural University)

  • Jian-Kang Zhu

    (Southern University of Science and Technology)

  • Hongwei Guo

    (Southern University of Science and Technology)

  • Ancheng C. Huang

    (Southern University of Science and Technology)

Abstract

Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor and signal central to cell metabolisms. Disrupting NAD homeostasis in plant alters growth and stress resistance, yet the underlying mechanisms remain largely unknown. Here, by combining genetics with multi-omics, we discover that NAD+ deficiency in qs-2 caused by mutation in NAD+ biosynthesis gene-Quinolinate Synthase retards growth but induces biosynthesis of defense compounds, notably aliphatic glucosinolates that confer insect resistance. The elevated defense in qs-2 is resulted from activated jasmonate biosynthesis, critically hydroperoxidation of α-linolenic acid by the 13-lipoxygenase (namely LOX2), which is escalated via the burst of chloroplastic ROS-singlet oxygen (1O2). The NAD+ deficiency-mediated JA induction and defense priming sequence in plants is recapitulated upon insect infestation, suggesting such defense mechanism operates in plant stress response. Hence, NAD homeostasis is a pivotal metabolic checkpoint that may be manipulated to navigate plant growth and defense metabolism for stress acclimation.

Suggested Citation

  • Yechun Hong & Zongjun Yu & Qian Zhou & Chunyu Chen & Yuqiong Hao & Zhen Wang & Jian-Kang Zhu & Hongwei Guo & Ancheng C. Huang, 2024. "NAD+ deficiency primes defense metabolism via 1O2-escalated jasmonate biosynthesis in plants," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51114-1
    DOI: 10.1038/s41467-024-51114-1
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