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Propofol disrupts the functional core-matrix architecture of the thalamus in humans

Author

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  • Zirui Huang

    (University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan)

  • George A. Mashour

    (University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan)

  • Anthony G. Hudetz

    (University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan Medical School
    University of Michigan)

Abstract

Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either the thalamus as a whole or focused on specific subregions, overlooking the distinct neuronal subtypes like core and matrix cells. We conducted a study of heathy volunteers and functional magnetic resonance imaging during conscious baseline, deep sedation, and recovery. We advanced the functional gradient mapping technique to delineate the functional geometry of thalamocortical circuits, within a framework of the unimodal-transmodal functional axis of the cortex. Here we show a significant shift in this geometry during deep sedation, marked by a transmodal-deficient geometry. This alteration is closely linked to the spatial variations in the matrix cell composition within the thalamus. This research bridges cellular and systems-level understanding, highlighting the crucial role of thalamic core–matrix functional architecture in understanding the neural mechanisms of states of consciousness.

Suggested Citation

  • Zirui Huang & George A. Mashour & Anthony G. Hudetz, 2024. "Propofol disrupts the functional core-matrix architecture of the thalamus in humans," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51837-1
    DOI: 10.1038/s41467-024-51837-1
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    References listed on IDEAS

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    1. Sakiko Honjoh & Shuntaro Sasai & Shannon S Schiereck & Hirotaka Nagai & Giulio Tononi & Chiara Cirelli, 2018. "Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    2. Michael J. Hawrylycz & Ed S. Lein & Angela L. Guillozet-Bongaarts & Elaine H. Shen & Lydia Ng & Jeremy A. Miller & Louie N. van de Lagemaat & Kimberly A. Smith & Amanda Ebbert & Zackery L. Riley & Chr, 2012. "An anatomically comprehensive atlas of the adult human brain transcriptome," Nature, Nature, vol. 489(7416), pages 391-399, September.
    3. Zirui Huang & George A. Mashour & Anthony G. Hudetz, 2023. "Functional geometry of the cortex encodes dimensions of consciousness," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. N. D. Schiff & J. T. Giacino & K. Kalmar & J. D. Victor & K. Baker & M. Gerber & B. Fritz & B. Eisenberg & J. O’Connor & E. J. Kobylarz & S. Farris & A. Machado & C. McCagg & F. Plum & J. J. Fins & A., 2007. "Behavioural improvements with thalamic stimulation after severe traumatic brain injury," Nature, Nature, vol. 448(7153), pages 600-603, August.
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