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Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus

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Listed:
  • Sakiko Honjoh

    (University of Wisconsin
    International Institute for Integrative Sleep Medicine)

  • Shuntaro Sasai

    (University of Wisconsin)

  • Shannon S Schiereck

    (University of Wisconsin)

  • Hirotaka Nagai

    (University of Wisconsin)

  • Giulio Tononi

    (University of Wisconsin)

  • Chiara Cirelli

    (University of Wisconsin)

Abstract

The “non-specific” ventromedial thalamic nucleus (VM) has long been considered a candidate for mediating cortical arousal due to its diffuse, superficial projections, but direct evidence was lacking. Here, we show in mice that the activity of VM calbindin1-positive matrix cells is high in wake and REM sleep and low in NREM sleep, and increases before cortical activity at the sleep-to-wake transition. Optogenetic stimulation of VM cells rapidly awoke all mice from NREM sleep and consistently caused EEG activation during slow wave anesthesia, while arousal did not occur from REM sleep. Conversely, chemogenetic inhibition of VM decreased wake duration. Optogenetic activation of the “specific” ventral posteromedial nucleus (VPM) did not cause arousal from either NREM or REM sleep. Thus, matrix cells in VM produce arousal and broad cortical activation during NREM sleep and slow wave anesthesia in a way that accounts for the effects classically attributed to “non-specific” thalamic nuclei.

Suggested Citation

  • Sakiko Honjoh & Shuntaro Sasai & Shannon S Schiereck & Hirotaka Nagai & Giulio Tononi & Chiara Cirelli, 2018. "Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04497-x
    DOI: 10.1038/s41467-018-04497-x
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    Cited by:

    1. Zirui Huang & George A. Mashour & Anthony G. Hudetz, 2024. "Propofol disrupts the functional core-matrix architecture of the thalamus in humans," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Beverly Setzer & Nina E. Fultz & Daniel E. P. Gomez & Stephanie D. Williams & Giorgio Bonmassar & Jonathan R. Polimeni & Laura D. Lewis, 2022. "A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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