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Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence

Author

Listed:
  • Xinyuan Liang

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Lianglong Sun

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Xuhong Liao

    (Beijing Normal University)

  • Tianyuan Lei

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Mingrui Xia

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Dingna Duan

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Zilong Zeng

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Qiongling Li

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Zhilei Xu

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Weiwei Men

    (Peking University
    Peking University)

  • Yanpei Wang

    (Beijing Normal University)

  • Shuping Tan

    (Peking University Huilongguan Clinical Medical School)

  • Jia-Hong Gao

    (Peking University
    Peking University
    Peking University)

  • Shaozheng Qin

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University
    Chinese Institute for Brain Research)

  • Sha Tao

    (Beijing Normal University)

  • Qi Dong

    (Beijing Normal University)

  • Tengda Zhao

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University)

  • Yong He

    (Beijing Normal University
    Beijing Normal University
    Beijing Normal University
    Chinese Institute for Brain Research)

Abstract

Cortical thinning is an important hallmark of the maturation of brain morphology during childhood and adolescence. However, the connectome-based wiring mechanism that underlies cortical maturation remains unclear. Here, we show cortical thinning patterns primarily located in the lateral frontal and parietal heteromodal nodes during childhood and adolescence, which are structurally constrained by white matter network architecture and are particularly represented using a network-based diffusion model. Furthermore, connectome-based constraints are regionally heterogeneous, with the largest constraints residing in frontoparietal nodes, and are associated with gene expression signatures of microstructural neurodevelopmental events. These results are highly reproducible in another independent dataset. These findings advance our understanding of network-level mechanisms and the associated genetic basis that underlies the maturational process of cortical morphology during childhood and adolescence.

Suggested Citation

  • Xinyuan Liang & Lianglong Sun & Xuhong Liao & Tianyuan Lei & Mingrui Xia & Dingna Duan & Zilong Zeng & Qiongling Li & Zhilei Xu & Weiwei Men & Yanpei Wang & Shuping Tan & Jia-Hong Gao & Shaozheng Qin , 2024. "Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44863-6
    DOI: 10.1038/s41467-024-44863-6
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    1. Leon D. Lotter & Amin Saberi & Justine Y. Hansen & Bratislav Misic & Casey Paquola & Gareth J. Barker & Arun L. W. Bokde & Sylvane Desrivières & Herta Flor & Antoine Grigis & Hugh Garavan & Penny Gowl, 2024. "Regional patterns of human cortex development correlate with underlying neurobiology," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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