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Behavioural improvements with thalamic stimulation after severe traumatic brain injury

Author

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  • N. D. Schiff

    (Weill Cornell Medical College, New York, New York 10021, USA)

  • J. T. Giacino

    (JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA
    New Jersey Neuroscience Institute, Edison, New Jersey 08818, USA)

  • K. Kalmar

    (JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA)

  • J. D. Victor

    (Weill Cornell Medical College, New York, New York 10021, USA)

  • K. Baker

    (Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA)

  • M. Gerber

    (JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA)

  • B. Fritz

    (JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA)

  • B. Eisenberg

    (JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA)

  • J. O’Connor

    (JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA)

  • E. J. Kobylarz

    (Weill Cornell Medical College, New York, New York 10021, USA)

  • S. Farris

    (Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA)

  • A. Machado

    (Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA)

  • C. McCagg

    (JFK Johnson Rehabilitation Institute, Edison, New Jersey 08818, USA)

  • F. Plum

    (Weill Cornell Medical College, New York, New York 10021, USA)

  • J. J. Fins

    (Weill Cornell Medical College, New York, New York 10021, USA)

  • A. R. Rezai

    (Center for Neurologic Restoration, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA)

Abstract

Brain activity revived At present there is no reliable way of enhancing recovery from extended loss of consciousness in patients with traumatic brain injury. But recent evidence suggesting that a level of cerebral activity is preserved in some minimally conscious patients has raised interest in the topic. In a single subject study, Schiff et al. show that bilateral deep brain stimulation in the thalamus in a minimally conscious state following brain injury can increase behavioural responsiveness and function. The observations, made six years after the injury, challenge current thinking on the management of patients with severe brain injury.

Suggested Citation

  • N. D. Schiff & J. T. Giacino & K. Kalmar & J. D. Victor & K. Baker & M. Gerber & B. Fritz & B. Eisenberg & J. O’Connor & E. J. Kobylarz & S. Farris & A. Machado & C. McCagg & F. Plum & J. J. Fins & A., 2007. "Behavioural improvements with thalamic stimulation after severe traumatic brain injury," Nature, Nature, vol. 448(7153), pages 600-603, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7153:d:10.1038_nature06041
    DOI: 10.1038/nature06041
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    Citations

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    Cited by:

    1. Daniel M Keenan & Amy W Quinkert & Donald W Pfaff, 2015. "Stochastic Modeling of Mouse Motor Activity under Deep Brain Stimulation: The Extraction of Arousal Information," PLOS Computational Biology, Public Library of Science, vol. 11(2), pages 1-24, February.
    2. Guttentag, Daniel A., 2010. "Virtual reality: Applications and implications for tourism," Tourism Management, Elsevier, vol. 31(5), pages 637-651.
    3. Zirui Huang & George A. Mashour & Anthony G. Hudetz, 2024. "Propofol disrupts the functional core-matrix architecture of the thalamus in humans," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Beverly Setzer & Nina E. Fultz & Daniel E. P. Gomez & Stephanie D. Williams & Giorgio Bonmassar & Jonathan R. Polimeni & Laura D. Lewis, 2022. "A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Andrea I. Luppi & Lynn Uhrig & Jordy Tasserie & Camilo M. Signorelli & Emmanuel A. Stamatakis & Alain Destexhe & Bechir Jarraya & Rodrigo Cofre, 2024. "Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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