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Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome

Author

Listed:
  • Pinpin Long

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Jiahui Si

    (Peking University)

  • Ziwei Zhu

    (Huazhong University of Science and Technology)

  • Yi Jiang

    (Huazhong University of Science and Technology)

  • Yufei Wang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Qin Jiang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Wending Li

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Xuedan Xu

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Yutong You

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Minghan Qu

    (Huazhong University of Science and Technology)

  • Huihui Wang

    (Huazhong University of Science and Technology)

  • Tingting Mo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Kang Liu

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Jing Jiang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Qiuhong Wang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Canqing Yu

    (Peking University Health Science Center
    Peking University Center for Public Health and Epidemic Preparedness & Response)

  • Yu Guo

    (Fuwai Hospital, Chinese Academy of Medical Sciences)

  • Iona Y. Millwood

    (University of Oxford
    University of Oxford)

  • Robin G. Walters

    (University of Oxford
    University of Oxford)

  • Ximiao He

    (Huazhong University of Science and Technology)

  • Yu Yuan

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Hao Wang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Xiaomin Zhang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Meian He

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Huan Guo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Zhengming Chen

    (University of Oxford
    University of Oxford)

  • Liming Li

    (Peking University Health Science Center
    Peking University Center for Public Health and Epidemic Preparedness & Response)

  • Jun Lv

    (Peking University Health Science Center
    Peking University Center for Public Health and Epidemic Preparedness & Response)

  • Chaolong Wang

    (Huazhong University of Science and Technology)

  • Tangchun Wu

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 nested case-control pairs). We identified and validated 26 differentially methylated positions (DMPs, false discovery rate [FDR]

Suggested Citation

  • Pinpin Long & Jiahui Si & Ziwei Zhu & Yi Jiang & Yufei Wang & Qin Jiang & Wending Li & Xuedan Xu & Yutong You & Minghan Qu & Huihui Wang & Tingting Mo & Kang Liu & Jing Jiang & Qiuhong Wang & Canqing , 2024. "Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51751-6
    DOI: 10.1038/s41467-024-51751-6
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    References listed on IDEAS

    as
    1. Yan Zhang & Rory Wilson & Jonathan Heiss & Lutz P. Breitling & Kai-Uwe Saum & Ben Schöttker & Bernd Holleczek & Melanie Waldenberger & Annette Peters & Hermann Brenner, 2017. "DNA methylation signatures in peripheral blood strongly predict all-cause mortality," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    2. Kyoko Watanabe & Erdogan Taskesen & Arjen Bochoven & Danielle Posthuma, 2017. "Functional mapping and annotation of genetic associations with FUMA," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

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