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Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Author

Listed:
  • Amirthagowri Ambalavanan

    (Queen’s University)

  • Le Chang

    (Queen’s University
    Queen’s University)

  • Jihoon Choi

    (Queen’s University)

  • Yang Zhang

    (Queen’s University)

  • Sara A. Stickley

    (Queen’s University)

  • Zhi Y. Fang

    (Queen’s University)

  • Kozeta Miliku

    (McMaster University
    University of Toronto)

  • Bianca Robertson

    (University of California San Diego)

  • Chloe Yonemitsu

    (University of California San Diego)

  • Stuart E. Turvey

    (University of British Columbia)

  • Piushkumar J. Mandhane

    (University of Alberta
    USCI University)

  • Elinor Simons

    (University of Manitoba)

  • Theo J. Moraes

    (Hospital for Sick Children and University of Toronto)

  • Sonia S. Anand

    (McMaster University)

  • Guillaume Paré

    (McMaster University)

  • Janet E. Williams

    (University of Idaho)

  • Brenda M. Murdoch

    (University of Idaho)

  • Gloria E. Otoo

    (University of Ghana)

  • Samwel Mbugua

    (Egerton University)

  • Elizabeth W. Kamau-Mbuthia

    (Egerton University)

  • Egidioh W. Kamundia

    (Egerton University)

  • Debela K. Gindola

    (Hawassa University)

  • Juan M. Rodriguez

    (Complutense University of Madrid)

  • Rossina G. Pareja

    (Nutrition Research Institute)

  • Daniel W. Sellen

    (University of Toronto)

  • Sophie E. Moore

    (King’s College London
    The Gambia at the London School of Hygiene & Tropical Medicine)

  • Andrew M. Prentice

    (The Gambia at the London School of Hygiene & Tropical Medicine)

  • James A. Foster

    (University of Idaho)

  • Linda J. Kvist

    (Lund University)

  • Holly L. Neibergs

    (Washington State University)

  • Mark A. McGuire

    (University of Idaho)

  • Michelle K. McGuire

    (University of Idaho)

  • Courtney L. Meehan

    (Washington State University)

  • Malcolm R. Sears

    (McMaster University)

  • Padmaja Subbarao

    (McMaster University
    Hospital for Sick Children and University of Toronto)

  • Meghan B. Azad

    (University of Manitoba
    Children’s Hospital Research Institute of Manitoba)

  • Lars Bode

    (University of California San Diego)

  • Qingling Duan

    (Queen’s University
    Queen’s University)

Abstract

Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e–118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6′-sialyllactose (P = 2.2e–9) in the sialyltransferase (ST6GAL1) gene. These, plus additional associations on chromosomes 7q21.32, 7q31.32 and 13q33.3, are replicated in the independent INSPIRE Cohort. Moreover, gene-environment interaction analyses suggest that fucosylated HMOs may modulate overall risk of recurrent wheeze among preschoolers with variable genetic risk scores (P

Suggested Citation

  • Amirthagowri Ambalavanan & Le Chang & Jihoon Choi & Yang Zhang & Sara A. Stickley & Zhi Y. Fang & Kozeta Miliku & Bianca Robertson & Chloe Yonemitsu & Stuart E. Turvey & Piushkumar J. Mandhane & Elino, 2024. "Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51743-6
    DOI: 10.1038/s41467-024-51743-6
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    References listed on IDEAS

    as
    1. Gordan Lauc & Abdelkader Essafi & Jennifer E Huffman & Caroline Hayward & Ana Knežević & Jayesh J Kattla & Ozren Polašek & Olga Gornik & Veronique Vitart & Jodie L Abrahams & Maja Pučić & Mislav Novok, 2010. "Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation," PLOS Genetics, Public Library of Science, vol. 6(12), pages 1-14, December.
    2. Kyoko Watanabe & Erdogan Taskesen & Arjen Bochoven & Danielle Posthuma, 2017. "Functional mapping and annotation of genetic associations with FUMA," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
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