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Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice

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  • David H. Sarrazin

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212)

  • Wilf Gardner

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212
    University of Strasbourg)

  • Carole Marchese

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212
    University of Strasbourg)

  • Martin Balzinger

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212
    University of Strasbourg)

  • Chockalingam Ramanathan

    (Medical Faculty)

  • Marion Schott

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212)

  • Stanislav Rozov

    (University of Helsinki
    University of Helsinki)

  • Maxime Veleanu

    (University of Freiburg)

  • Stefan Vestring

    (University of Freiburg
    University of Freiburg)

  • Claus Normann

    (University of Freiburg
    University of Freiburg)

  • Tomi Rantamäki

    (University of Helsinki
    University of Helsinki)

  • Benedicte Antoine

    (Centre de Recherches St‐Antoine (CRSA))

  • Michel Barrot

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212
    University of Strasbourg)

  • Etienne Challet

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212)

  • Patrice Bourgin

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212
    Strasbourg University Hospital)

  • Tsvetan Serchov

    (Institute of Cellular and Integrative Neurosciences (INCI) UPR 3212
    University of Strasbourg
    University of Freiburg)

Abstract

Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant ketamine. Selective Bmal1KO in CaMK2a excitatory neurons revealed that the functional mPFC clock is an essential factor for the development of a depression-like phenotype and ketamine effects. Per2 silencing in mPFC produced antidepressant-like effects, while REV-ERB agonism enhanced the depression-like phenotype and suppressed ketamine action. Pharmacological potentiation of clock positive modulator ROR elicited antidepressant-like effects, upregulating plasticity protein Homer1a, synaptic AMPA receptors expression and plasticity-related slow wave activity specifically in the mPFC. Our data demonstrate a critical role for mPFC molecular clock in regulating depression-like behavior and the therapeutic potential of clock pharmacological manipulations influencing glutamatergic-dependent plasticity.

Suggested Citation

  • David H. Sarrazin & Wilf Gardner & Carole Marchese & Martin Balzinger & Chockalingam Ramanathan & Marion Schott & Stanislav Rozov & Maxime Veleanu & Stefan Vestring & Claus Normann & Tomi Rantamäki & , 2024. "Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51716-9
    DOI: 10.1038/s41467-024-51716-9
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