IDEAS home Printed from https://ideas.repec.org/a/eee/phsmap/v457y2016icp62-72.html
   My bibliography  Save this article

Coupling mechanism in the gate and oscillator model of the SCN

Author

Listed:
  • Li, Ying
  • Liu, Zengrong

Abstract

In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is considered as the master circadian pacemaker. The SCN is divided into two subgroups of gate and oscillator cells: the ventrolateral (VL) neurons, which receive the periodic light-dark (LD) signal, and the dorsomedial (DM) neurons, which are coupled to the VL cells. The fundamental question is how the individual cellular oscillators, expressing a wide range of periods, interact and assemble to create an integrated pacemaker that can govern behavioral and physiological rhythmicity and be reset by environmental light. The key is that the heterogeneous network formed by the cellular clocks within the SCN must synchronize to maintain timekeeping activity. Based on the structural and functional heterogeneity of the SCN, the authors bring forward a mathematical model including gate cells and oscillator cells with a wide range of periods. The gate neurons offer daily injection to oscillator neurons and the activation of gate is determined by the output of the oscillator neurons. In this model, the authors consider two kinds of coupling: interior coupling among the oscillator cells and exterior coupling from the gate cells to the oscillator cells. The authors mainly analyze the combined effects of these two kinds of coupling on the entrainment of the oscillator cells in the DM part. It is found that the interior coupling is conducive to entrainment, but a stronger coupling is not beneficial to entrainment. The gate mechanism in exterior coupling is more propitious to entrainment than continuous coupling. This study helps to understand collective circadian rhythm in the mammals.

Suggested Citation

  • Li, Ying & Liu, Zengrong, 2016. "Coupling mechanism in the gate and oscillator model of the SCN," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 457(C), pages 62-72.
  • Handle: RePEc:eee:phsmap:v:457:y:2016:i:c:p:62-72
    DOI: 10.1016/j.physa.2016.03.105
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378437116301030
    Download Restriction: Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000

    File URL: https://libkey.io/10.1016/j.physa.2016.03.105?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Li, Ying & Liu, Zengrong, 2015. "Dynamical mechanism of Bmal1/Rev-erbα loop in circadian clock," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 430(C), pages 126-135.
    2. Mian Zhou & Wei Wang & Sargis Karapetyan & Musoki Mwimba & Jorge Marqués & Nicolas E. Buchler & Xinnian Dong, 2015. "Redox rhythm reinforces the circadian clock to gate immune response," Nature, Nature, vol. 523(7561), pages 472-476, July.
    3. Steven M. Reppert & David R. Weaver, 2002. "Coordination of circadian timing in mammals," Nature, Nature, vol. 418(6901), pages 935-941, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Francesco Riganello & Valeria Prada & Andres Soddu & Carol di Perri & Walter G. Sannita, 2019. "Circadian Rhythms and Measures of CNS/Autonomic Interaction," IJERPH, MDPI, vol. 16(13), pages 1-11, July.
    2. Purificación Gómez-Abellán & Antoni Díez-Noguera & Juan A Madrid & Juan A Luján & José M Ordovás & Marta Garaulet, 2012. "Glucocorticoids Affect 24 h Clock Genes Expression in Human Adipose Tissue Explant Cultures," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-10, December.
    3. Nguyen, Ha Trong & Zubrick, Stephen R. & Mitrou, Francis, 2024. "The effects of sleep duration on child health and development," Journal of Economic Behavior & Organization, Elsevier, vol. 221(C), pages 35-51.
    4. Qiang Bao & Di Liu & Yujiao Guo & Wang Gu & Zhengfeng Cao & Yu Zhang & Yang Zhang & Qi Xu & Guohong Chen, 2023. "Melatonin Secretion in Regulating the Circadian Rhythms of Reproduction in Goose ( Anser cygnoides )," Agriculture, MDPI, vol. 13(8), pages 1-16, August.
    5. Francisco J Sánchez Muniz & Cristina Simón Martín, 2017. "Clock Genes, Chronodisruption, Nutrition and Obesity," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 3(2), pages 1-62:3, July.
    6. Henson, Michael A., 2013. "Multicellular models of intercellular synchronization in circadian neural networks," Chaos, Solitons & Fractals, Elsevier, vol. 50(C), pages 48-64.
    7. Andrew E. Warfield & Pooja Gupta & Madison M. Ruhmann & Quiana L. Jeffs & Genevieve C. Guidone & Hannah W. Rhymes & McKenzi I. Thompson & William D. Todd, 2023. "A brainstem to circadian system circuit links Tau pathology to sundowning-related disturbances in an Alzheimer’s disease mouse model," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    8. Zhengying Luo & Xin Hu & Zhuandi Wu & Xinlong Liu & Caiwen Wu & Qianchun Zeng, 2022. "Identification and Expression Profiling of TGA Transcription Factor Genes in Sugarcane Reveals the Roles in Response to Sporisorium scitamineum Infection," Agriculture, MDPI, vol. 12(10), pages 1-15, October.
    9. Cheng-Kang Chiang & Neel Mehta & Abhilasha Patel & Peng Zhang & Zhibin Ning & Janice Mayne & Warren Y L Sun & Hai-Ying M Cheng & Daniel Figeys, 2014. "The Proteomic Landscape of the Suprachiasmatic Nucleus Clock Reveals Large-Scale Coordination of Key Biological Processes," PLOS Genetics, Public Library of Science, vol. 10(10), pages 1-15, October.
    10. Li, Ying & Liu, Zengrong, 2015. "Dynamical mechanism of Bmal1/Rev-erbα loop in circadian clock," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 430(C), pages 126-135.
    11. Sumedha W Karmarkar & Kathleen M Bottum & Stacey L Krager & Shelley A Tischkau, 2011. "ERK/MAPK Is Essential for Endogenous Neuroprotection in SCN2.2 Cells," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-13, August.
    12. Valerie L Harbour & Yuval Weigl & Barry Robinson & Shimon Amir, 2013. "Comprehensive Mapping of Regional Expression of the Clock Protein PERIOD2 in Rat Forebrain across the 24-h Day," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-14, October.
    13. O. Slaby & S. Sager & O. S. Shaik & U. Kummer & D. Lebiedz, 2007. "Optimal control of self-organized dynamics in cellular signal transduction," Mathematical and Computer Modelling of Dynamical Systems, Taylor & Francis Journals, vol. 13(5), pages 487-502, October.
    14. Gaële Lajeunesse & Charles Roussin-Léveillée & Sophie Boutin & Élodie Fortin & Isabelle Laforest-Lapointe & Peter Moffett, 2023. "Light prevents pathogen-induced aqueous microenvironments via potentiation of salicylic acid signaling," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    15. Michal Dudek & Dharshika R. J. Pathiranage & Beatriz Bano-Otalora & Anna Paszek & Natalie Rogers & Cátia F. Gonçalves & Craig Lawless & Dong Wang & Zhuojing Luo & Liu Yang & Farshid Guilak & Judith A., 2023. "Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    16. René Carmona & Christy V. Graves, 2020. "Jet Lag Recovery: Synchronization of Circadian Oscillators as a Mean Field Game," Dynamic Games and Applications, Springer, vol. 10(1), pages 79-99, March.
    17. David H. Sarrazin & Wilf Gardner & Carole Marchese & Martin Balzinger & Chockalingam Ramanathan & Marion Schott & Stanislav Rozov & Maxime Veleanu & Stefan Vestring & Claus Normann & Tomi Rantamäki & , 2024. "Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    18. Jing Wang & Haibo Di & Steven Laureys & Nantu Hu, 2018. "Circadian Rhythm of Patients with Disorders of Consciousness," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 9(3), pages 60-61, November.
    19. Yan-Ying Wang & Wei-Wei Ma & I-Feng Peng, 2020. "Screening of sleep assisting drug candidates with a Drosophila model," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-17, July.
    20. Hyeri Nam & Younghwan Lee & Boil Kim & Ji-Won Lee & Seohyeon Hwang & Hyun-Kyu An & Kyung Min Chung & Youngjin Park & Jihyun Hong & Kyungjin Kim & Eun-Kyoung Kim & Han Kyoung Choe & Seong-Woon Yu, 2022. "Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:phsmap:v:457:y:2016:i:c:p:62-72. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/physica-a-statistical-mechpplications/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.