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Ultraselective Macrocycle Membranes for Pharmaceutical Ingredients Separation in Organic Solvents

Author

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  • Banan Alhazmi

    (King Abdullah University of Science and Technology (KAUST))

  • Gergo Ignacz

    (King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology (KAUST))

  • Maria Vincenzo

    (King Abdullah University of Science and Technology (KAUST))

  • Mohamed Nejib Hedhili

    (King Abdullah University of Science and Technology (KAUST))

  • Gyorgy Szekely

    (King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology (KAUST))

  • Suzana P. Nunes

    (King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology (KAUST)
    King Abdullah University of Science and Technology (KAUST))

Abstract

Separations are core processes in the chemical and pharmaceutical industries. Several steps of fractionation and purification of multicomponent mixtures are required. Membrane technology can operate at fair temperatures, saving energy and processing sensitive compounds. However, breakthroughs require high stability and selectivity beyond those available today. Here, we propose membranes constituted by fully crosslinked crown ethers using interfacial polymerization. The 24 nm-thick nanofilms on robust porous supports exhibit up to 90% higher selectivity than commercially available membranes, with a 90% increase in solvent permeance. The membranes are tested with a complex mixture of structurally diverse solutes containing active pharmaceutical ingredients. The membranes are effective for the total retention and concentration of active pharmaceutical ingredients with molecular weights around 800 g mol–1. The ability to distinguish between smaller molecules in the range between 100 and 370 g mol–1 is confirmed with high separation factors, which could provide a significant advance for the pharmaceutical industry.

Suggested Citation

  • Banan Alhazmi & Gergo Ignacz & Maria Vincenzo & Mohamed Nejib Hedhili & Gyorgy Szekely & Suzana P. Nunes, 2024. "Ultraselective Macrocycle Membranes for Pharmaceutical Ingredients Separation in Organic Solvents," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51548-7
    DOI: 10.1038/s41467-024-51548-7
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    References listed on IDEAS

    as
    1. Zhiwei Jiang & Ruijiao Dong & Austin M. Evans & Niklas Biere & Mahmood A. Ebrahim & Siyao Li & Dario Anselmetti & William R. Dichtel & Andrew G. Livingston, 2022. "Aligned macrocycle pores in ultrathin films for accurate molecular sieving," Nature, Nature, vol. 609(7925), pages 58-64, September.
    2. Xiang Li & Weibin Lin & Vivekanand Sharma & Radoslaw Gorecki & Munmun Ghosh & Basem A. Moosa & Sandra Aristizabal & Shanshan Hong & Niveen M. Khashab & Suzana P. Nunes, 2023. "Polycage membranes for precise molecular separation and catalysis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Tiefan Huang & Basem A. Moosa & Phuong Hoang & Jiangtao Liu & Stefan Chisca & Gengwu Zhang & Mram AlYami & Niveen M. Khashab & Suzana P. Nunes, 2020. "Molecularly-porous ultrathin membranes for highly selective organic solvent nanofiltration," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
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