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Wrapping stem cells with wireless electrical nanopatches for traumatic brain injury therapy

Author

Listed:
  • Liang Wang

    (Shandong University)

  • Jingyi Du

    (School of Basic Medical Sciences, Shandong University
    School of Basic Medical Sciences, Shandong University)

  • Qilu Liu

    (Shandong University)

  • Dongshuang Wang

    (School of Basic Medical Sciences, Shandong University
    School of Basic Medical Sciences, Shandong University)

  • Wenhan Wang

    (Shandong University)

  • Ming Lei

    (Shandong University)

  • Keyi Li

    (Shandong University)

  • Yiwei Li

    (Shandong University)

  • Aijun Hao

    (School of Basic Medical Sciences, Shandong University
    School of Basic Medical Sciences, Shandong University)

  • Yuanhua Sang

    (Shandong University)

  • Fan Yi

    (School of Basic Medical Sciences, Shandong University)

  • Wenjuan Zhou

    (School of Basic Medical Sciences, Shandong University
    School of Basic Medical Sciences, Shandong University)

  • Hong Liu

    (Shandong University)

  • Chuanbin Mao

    (The Chinese University of Hong Kong, Sha Tin)

  • Jichuan Qiu

    (Shandong University)

Abstract

Electrical stimulation holds promise for enhancing neuronal differentiation of neural stem cells to treat traumatic brain injury. However, once the stem cells leave the stimulating material and migrate post transplantation, electrical stimulation on them is diminished. Here, we wrap the stem cells with wireless electrical nanopatches, the conductive graphene nanosheets. Under electromagnetic induction, electrical stimulation can thus be applied in-situ to individual nanopatch-wrapped stem cells on demand, stimulating their neuronal differentiation through a MAPK/ERK signaling pathway. Consequently, 41% of the nanopatch-wrapped stem cells differentiate into functional neurons in 5 days, as opposed to only 16.3% of the unwrapped ones. The brain injury male mice implanted with the nanopatch-wrapped stem cells and exposed to a rotating magnetic field 30 min/day exhibit significant recovery of brain tissues, behaviors, and cognitions, within 28 days. This study opens up an avenue to individualized electrical stimulation of transplanted stem cells for treating neurodegenerative diseases.

Suggested Citation

  • Liang Wang & Jingyi Du & Qilu Liu & Dongshuang Wang & Wenhan Wang & Ming Lei & Keyi Li & Yiwei Li & Aijun Hao & Yuanhua Sang & Fan Yi & Wenjuan Zhou & Hong Liu & Chuanbin Mao & Jichuan Qiu, 2024. "Wrapping stem cells with wireless electrical nanopatches for traumatic brain injury therapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51098-y
    DOI: 10.1038/s41467-024-51098-y
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    References listed on IDEAS

    as
    1. Bingyao Zhu & Jisu Eom & Robert F. Hunt, 2019. "Transplanted interneurons improve memory precision after traumatic brain injury," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    2. Yanjing Zhu & Ruiqi Huang & Zhourui Wu & Simin Song & Liming Cheng & Rongrong Zhu, 2021. "Deep learning-based predictive identification of neural stem cell differentiation," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Zhixiong Sun & Xiguang Xu & Jianlin He & Alexander Murray & Ming-an Sun & Xiaoran Wei & Xia Wang & Emmarose McCoig & Evan Xie & Xi Jiang & Liwu Li & Jinsong Zhu & Jianjun Chen & Alexei Morozov & Alici, 2019. "EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    4. Susanne Falkner & Sofia Grade & Leda Dimou & Karl-Klaus Conzelmann & Tobias Bonhoeffer & Magdalena Götz & Mark Hübener, 2016. "Transplanted embryonic neurons integrate into adult neocortical circuits," Nature, Nature, vol. 539(7628), pages 248-253, November.
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