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Transplanted embryonic neurons integrate into adult neocortical circuits

Author

Listed:
  • Susanne Falkner

    (Max Planck Institute of Neurobiology)

  • Sofia Grade

    (Physiological Genomics, Biomedical Center, Ludwig-Maximilians University Munich
    Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health)

  • Leda Dimou

    (Physiological Genomics, Biomedical Center, Ludwig-Maximilians University Munich
    Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health
    SYNERGY, Excellence Cluster of Systems Neurology, Biomedical Center, Ludwig-Maximilians University Munich)

  • Karl-Klaus Conzelmann

    (Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians University Munich)

  • Tobias Bonhoeffer

    (Max Planck Institute of Neurobiology)

  • Magdalena Götz

    (Physiological Genomics, Biomedical Center, Ludwig-Maximilians University Munich
    Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health
    SYNERGY, Excellence Cluster of Systems Neurology, Biomedical Center, Ludwig-Maximilians University Munich)

  • Mark Hübener

    (Max Planck Institute of Neurobiology)

Abstract

The ability of the adult mammalian brain to compensate for neuronal loss caused by injury or disease is very limited. Transplantation aims to replace lost neurons, but the extent to which new neurons can integrate into existing circuits is unknown. Here, using chronic in vivo two-photon imaging, we show that embryonic neurons transplanted into the visual cortex of adult mice mature into bona fide pyramidal cells with selective pruning of basal dendrites, achieving adult-like densities of dendritic spines and axonal boutons within 4–8 weeks. Monosynaptic tracing experiments reveal that grafted neurons receive area-specific, afferent inputs matching those of pyramidal neurons in the normal visual cortex, including topographically organized geniculo-cortical connections. Furthermore, stimulus-selective responses refine over the course of many weeks and finally become indistinguishable from those of host neurons. Thus, grafted neurons can integrate with great specificity into neocortical circuits that normally never incorporate new neurons in the adult brain.

Suggested Citation

  • Susanne Falkner & Sofia Grade & Leda Dimou & Karl-Klaus Conzelmann & Tobias Bonhoeffer & Magdalena Götz & Mark Hübener, 2016. "Transplanted embryonic neurons integrate into adult neocortical circuits," Nature, Nature, vol. 539(7628), pages 248-253, November.
  • Handle: RePEc:nat:nature:v:539:y:2016:i:7628:d:10.1038_nature20113
    DOI: 10.1038/nature20113
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    Cited by:

    1. Harman Ghuman & Kyungsoo Kim & Sapeeda Barati & Karunesh Ganguly, 2023. "Emergence of task-related spatiotemporal population dynamics in transplanted neurons," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Laura Empl & Alexandra Chovsepian & Maryam Chahin & Wing Yin Vanessa Kan & Julie Fourneau & Valérie Steenbergen & Sanofer Weidinger & Maite Marcantoni & Alexander Ghanem & Peter Bradley & Karl Klaus C, 2022. "Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Liang Wang & Jingyi Du & Qilu Liu & Dongshuang Wang & Wenhan Wang & Ming Lei & Keyi Li & Yiwei Li & Aijun Hao & Yuanhua Sang & Fan Yi & Wenjuan Zhou & Hong Liu & Chuanbin Mao & Jichuan Qiu, 2024. "Wrapping stem cells with wireless electrical nanopatches for traumatic brain injury therapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Balazs V. Varga & Maryam Faiz & Helena Pivonkova & Gabriel Khelifi & Huijuan Yang & Shangbang Gao & Emma Linderoth & Mei Zhen & Ragnhildur Thora Karadottir & Samer M. Hussein & Andras Nagy, 2022. "Signal requirement for cortical potential of transplantable human neuroepithelial stem cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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