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Transplanted interneurons improve memory precision after traumatic brain injury

Author

Listed:
  • Bingyao Zhu

    (University of California)

  • Jisu Eom

    (University of California)

  • Robert F. Hunt

    (University of California
    University of California
    University of California)

Abstract

Repair of the traumatically injured brain has been envisioned for decades, but regenerating new neurons at the site of brain injury has been challenging. We show GABAergic progenitors, derived from the embryonic medial ganglionic eminence, migrate long distances following transplantation into the hippocampus of adult mice with traumatic brain injury, functionally integrate as mature inhibitory interneurons and restore post-traumatic decreases in synaptic inhibition. Grafted animals had improvements in memory precision that were reversed by chemogenetic silencing of the transplanted neurons and a long-lasting reduction in spontaneous seizures. Our results reveal a striking ability of transplanted interneurons for incorporating into injured brain circuits, and this approach is a powerful therapeutic strategy for correcting post-traumatic memory and seizure disorders.

Suggested Citation

  • Bingyao Zhu & Jisu Eom & Robert F. Hunt, 2019. "Transplanted interneurons improve memory precision after traumatic brain injury," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13170-w
    DOI: 10.1038/s41467-019-13170-w
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    Cited by:

    1. Harman Ghuman & Kyungsoo Kim & Sapeeda Barati & Karunesh Ganguly, 2023. "Emergence of task-related spatiotemporal population dynamics in transplanted neurons," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Jan C. Frankowski & Alexa Tierno & Shreya Pavani & Quincy Cao & David C. Lyon & Robert F. Hunt, 2022. "Brain-wide reconstruction of inhibitory circuits after traumatic brain injury," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Liang Wang & Jingyi Du & Qilu Liu & Dongshuang Wang & Wenhan Wang & Ming Lei & Keyi Li & Yiwei Li & Aijun Hao & Yuanhua Sang & Fan Yi & Wenjuan Zhou & Hong Liu & Chuanbin Mao & Jichuan Qiu, 2024. "Wrapping stem cells with wireless electrical nanopatches for traumatic brain injury therapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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