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Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

Author

Listed:
  • Hansol Lim

    (Max Planck Institute for Biological Intelligence)

  • Yue Zhang

    (Max Planck Institute for Biological Intelligence)

  • Christian Peters

    (Max Planck Institute for Biological Intelligence)

  • Tobias Straub

    (LMU)

  • Johanna Luise Mayer

    (Max Planck Institute for Biological Intelligence)

  • Rüdiger Klein

    (Max Planck Institute for Biological Intelligence)

Abstract

The basolateral amygdala (BLA) contains discrete neuronal circuits that integrate positive or negative emotional information and drive the appropriate innate and learned behaviors. Whether these circuits consist of genetically-identifiable and anatomically segregated neuron types, is poorly understood. Also, our understanding of the response patterns and behavioral spectra of genetically-identifiable BLA neurons is limited. Here, we classified 11 glutamatergic cell clusters in mouse BLA and found that several of them were anatomically segregated in lateral versus basal amygdala, and anterior versus posterior regions of the BLA. Two of these BLA subpopulations innately responded to valence-specific, whereas one responded to mixed - aversive and social - cues. Positive-valence BLA neurons promoted normal feeding, while mixed selectivity neurons promoted fear learning and social interactions. These findings enhance our understanding of cell type diversity and spatial organization of the BLA and the role of distinct BLA populations in representing valence-specific and mixed stimuli.

Suggested Citation

  • Hansol Lim & Yue Zhang & Christian Peters & Tobias Straub & Johanna Luise Mayer & Rüdiger Klein, 2024. "Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50889-7
    DOI: 10.1038/s41467-024-50889-7
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