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Connectivity characterization of the mouse basolateral amygdalar complex

Author

Listed:
  • Houri Hintiryan

    (University of Southern California
    University of California)

  • Ian Bowman

    (University of Southern California
    University of California)

  • David L. Johnson

    (University of Southern California)

  • Laura Korobkova

    (University of Southern California)

  • Muye Zhu

    (University of Southern California
    University of California)

  • Neda Khanjani

    (University of Southern California)

  • Lin Gou

    (University of Southern California
    University of California)

  • Lei Gao

    (University of Southern California
    University of California)

  • Seita Yamashita

    (University of Southern California
    University of California)

  • Michael S. Bienkowski

    (University of Southern California
    University of Southern California)

  • Luis Garcia

    (University of Southern California
    University of California)

  • Nicholas N. Foster

    (University of Southern California
    University of California)

  • Nora L. Benavidez

    (University of Southern California)

  • Monica Y. Song

    (University of Southern California)

  • Darrick Lo

    (University of Southern California
    University of California)

  • Kaelan R. Cotter

    (University of Southern California
    University of California)

  • Marlene Becerra

    (University of Southern California)

  • Sarvia Aquino

    (University of Southern California)

  • Chunru Cao

    (University of Southern California
    University of California)

  • Ryan P. Cabeen

    (University of Southern California)

  • Jim Stanis

    (University of Southern California)

  • Marina Fayzullina

    (University of Southern California)

  • Sarah A. Ustrell

    (University of Southern California)

  • Tyler Boesen

    (University of Southern California
    University of California)

  • Amanda J. Tugangui

    (University of Southern California
    University of California)

  • Zheng-Gang Zhang

    (University of Southern California
    Southern Medical University)

  • Bo Peng

    (University of Southern California)

  • Michael S. Fanselow

    (University of California)

  • Peyman Golshani

    (University of California
    University of California
    West Los Angeles Veterans Administration Medical Center)

  • Joel D. Hahn

    (University of Southern California)

  • Ian R. Wickersham

    (Massachusetts Institute of Technology)

  • Giorgio A. Ascoli

    (George Mason University)

  • Li I. Zhang

    (University of Southern California)

  • Hong-Wei Dong

    (University of Southern California
    University of California)

Abstract

The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions to uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile of BLA projection neurons to inform granular, cell type-specific interrogations is warranted. Here, we apply machine-learning based computational and informatics analysis techniques to the results of circuit-tracing experiments to create a foundational, comprehensive BLA connectivity map. The analyses identify three distinct domains within the anterior BLA (BLAa) that house target-specific projection neurons with distinguishable morphological features. We identify brain-wide targets of projection neurons in the three BLAa domains, as well as in the posterior BLA, ventral BLA, posterior basomedial, and lateral amygdalar nuclei. Inputs to each nucleus also are identified via retrograde tracing. The data suggests that connectionally unique, domain-specific BLAa neurons are associated with distinct behavior networks.

Suggested Citation

  • Houri Hintiryan & Ian Bowman & David L. Johnson & Laura Korobkova & Muye Zhu & Neda Khanjani & Lin Gou & Lei Gao & Seita Yamashita & Michael S. Bienkowski & Luis Garcia & Nicholas N. Foster & Nora L. , 2021. "Connectivity characterization of the mouse basolateral amygdalar complex," Nature Communications, Nature, vol. 12(1), pages 1-25, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22915-5
    DOI: 10.1038/s41467-021-22915-5
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    Cited by:

    1. Ren-Wen Han & Zi-Yi Zhang & Chen Jiao & Ze-Yu Hu & Bing-Xing Pan, 2024. "Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Léa J. Becker & Clémentine Fillinger & Robin Waegaert & Sarah H. Journée & Pierre Hener & Beyza Ayazgok & Muris Humo & Meltem Karatas & Maxime Thouaye & Mithil Gaikwad & Laetitia Degiorgis & Marie des, 2023. "The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    4. Siva Venkadesh & Anthony Santarelli & Tyler Boesen & Hong-Wei Dong & Giorgio A. Ascoli, 2023. "Combinatorial quantification of distinct neural projections from retrograde tracing," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Hansol Lim & Yue Zhang & Christian Peters & Tobias Straub & Johanna Luise Mayer & Rüdiger Klein, 2024. "Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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