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From circuits to behaviour in the amygdala

Author

Listed:
  • Patricia H. Janak

    (Johns Hopkins University
    Johns Hopkins University)

  • Kay M. Tye

    (Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

Abstract

The amygdala has long been associated with emotion and motivation, playing an essential part in processing both fearful and rewarding environmental stimuli. How can a single structure be crucial for such different functions? With recent technological advances that allow for causal investigations of specific neural circuit elements, we can now begin to map the complex anatomical connections of the amygdala onto behavioural function. Understanding how the amygdala contributes to a wide array of behaviours requires the study of distinct amygdala circuits.

Suggested Citation

  • Patricia H. Janak & Kay M. Tye, 2015. "From circuits to behaviour in the amygdala," Nature, Nature, vol. 517(7534), pages 284-292, January.
    • Handle: RePEc:nat:nature:v:517:y:2015:i:7534:d:10.1038_nature14188
    DOI: 10.1038/nature14188
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    Cited by:

    1. Mariusz Mucha & Anna E. Skrzypiec & Jaison B. Kolenchery & Valentina Brambilla & Satyam Patel & Alberto Labrador-Ramos & Lucja Kudla & Kathryn Murrall & Nathan Skene & Violetta Dymicka-Piekarska & Aga, 2023. "miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Lahti, Tom & Halko, Marja-Liisa & Karagozoglu, Necmi & Wincent, Joakim, 2019. "Why and how do founding entrepreneurs bond with their ventures? Neural correlates of entrepreneurial and parental bonding," Journal of Business Venturing, Elsevier, vol. 34(2), pages 368-388.
    3. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Kazuhisa Shibata & Takeo Watanabe & Mitsuo Kawato & Yuka Sasaki, 2016. "Differential Activation Patterns in the Same Brain Region Led to Opposite Emotional States," PLOS Biology, Public Library of Science, vol. 14(9), pages 1-27, September.
    5. Ren-Wen Han & Zi-Yi Zhang & Chen Jiao & Ze-Yu Hu & Bing-Xing Pan, 2024. "Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    6. Dheeraj S. Roy & Young-Gyun Park & Minyoung E. Kim & Ying Zhang & Sachie K. Ogawa & Nicholas DiNapoli & Xinyi Gu & Jae H. Cho & Heejin Choi & Lee Kamentsky & Jared Martin & Olivia Mosto & Tomomi Aida , 2022. "Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. In Bum Lee & Eugene Lee & Na-Eun Han & Marko Slavuj & Jeong Wook Hwang & Ahrim Lee & Taeyoung Sun & Yehwan Jeong & Ja-Hyun Baik & Jae-Yong Park & Se-Young Choi & Jeehyun Kwag & Bong-June Yoon, 2024. "Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. Gayane Aghakhanyan & Paolo Bonanni & Giovanna Randazzo & Sara Nappi & Federica Tessarotto & Lara De Martin & Francesca Frijia & Daniele De Marchi & Francesco De Masi & Beate Kuppers & Francesco Lombar, 2016. "From Cortical and Subcortical Grey Matter Abnormalities to Neurobehavioral Phenotype of Angelman Syndrome: A Voxel-Based Morphometry Study," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-17, September.
    9. Feng Zhou & Weihua Zhao & Ziyu Qi & Yayuan Geng & Shuxia Yao & Keith M. Kendrick & Tor D. Wager & Benjamin Becker, 2021. "A distributed fMRI-based signature for the subjective experience of fear," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    10. Owen Y. Chao & Salil Saurav Pathak & Hao Zhang & George J. Augustine & Jason M. Christie & Chikako Kikuchi & Hiroki Taniguchi & Yi-Mei Yang, 2023. "Social memory deficit caused by dysregulation of the cerebellar vermis," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    11. Hansol Lim & Yue Zhang & Christian Peters & Tobias Straub & Johanna Luise Mayer & Rüdiger Klein, 2024. "Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    12. Huiling Yu & Liping Chen & Huiyang Lei & Guilin Pi & Rui Xiong & Tao Jiang & Dongqin Wu & Fei Sun & Yang Gao & Yuanhao Li & Wenju Peng & Bingyu Huang & Guoda Song & Xin Wang & Jingru Lv & Zetao Jin & , 2022. "Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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