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A circuit mechanism for differentiating positive and negative associations

Author

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  • Praneeth Namburi

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Neuroscience Graduate Program, Massachusetts Institute of Technology)

  • Anna Beyeler

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Suzuko Yorozu

    (Harvard Medical School)

  • Gwendolyn G. Calhoon

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Sarah A. Halbert

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Undergraduate Program in Neuroscience, Wellesley College)

  • Romy Wichmann

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

  • Stephanie S. Holden

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Undergraduate Program in Neuroscience, Massachusetts Institute of Technology)

  • Kim L. Mertens

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Master’s Program in Biomedical Sciences, University of Amsterdam)

  • Melodi Anahtar

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Undergraduate Program in Neuroscience, Massachusetts Institute of Technology)

  • Ada C. Felix-Ortiz

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
    Neuroscience Graduate Program, Massachusetts Institute of Technology)

  • Ian R. Wickersham

    (McGovern Institute for Brain Research, Massachusetts Institute of Technology)

  • Jesse M. Gray

    (Harvard Medical School)

  • Kay M. Tye

    (The Picower Institute for Learning and Memory, Massachusetts Institute of Technology)

Abstract

Neurons in the basolateral amygdala projecting to canonical fear or reward circuits undergo opposing changes in synaptic strength following fear or reward conditioning, and selectively activating these projection-target-defined neural populations causes either negative or positive reinforcement, respectively.

Suggested Citation

  • Praneeth Namburi & Anna Beyeler & Suzuko Yorozu & Gwendolyn G. Calhoon & Sarah A. Halbert & Romy Wichmann & Stephanie S. Holden & Kim L. Mertens & Melodi Anahtar & Ada C. Felix-Ortiz & Ian R. Wickersh, 2015. "A circuit mechanism for differentiating positive and negative associations," Nature, Nature, vol. 520(7549), pages 675-678, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7549:d:10.1038_nature14366
    DOI: 10.1038/nature14366
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    Cited by:

    1. C. Nicolas & A. Ju & Y. Wu & H. Eldirdiri & S. Delcasso & Y. Couderc & C. Fornari & A. Mitra & L. Supiot & A. Vérité & M. Masson & S. Rodriguez-Rozada & D. Jacky & J. S. Wiegert & A. Beyeler, 2023. "Linking emotional valence and anxiety in a mouse insula-amygdala circuit," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Léa J. Becker & Clémentine Fillinger & Robin Waegaert & Sarah H. Journée & Pierre Hener & Beyza Ayazgok & Muris Humo & Meltem Karatas & Maxime Thouaye & Mithil Gaikwad & Laetitia Degiorgis & Marie des, 2023. "The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    3. Hansol Lim & Yue Zhang & Christian Peters & Tobias Straub & Johanna Luise Mayer & Rüdiger Klein, 2024. "Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    4. Huiling Yu & Liping Chen & Huiyang Lei & Guilin Pi & Rui Xiong & Tao Jiang & Dongqin Wu & Fei Sun & Yang Gao & Yuanhao Li & Wenju Peng & Bingyu Huang & Guoda Song & Xin Wang & Jingru Lv & Zetao Jin & , 2022. "Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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