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Light-responsive adipose-hypothalamus axis controls metabolic regulation

Author

Listed:
  • Tadataka Tsuji

    (Harvard Medical School)

  • Vladimir Tolstikov

    (BPGbio)

  • Yang Zhang

    (Harvard Medical School)

  • Tian Lian Huang

    (Harvard Medical School)

  • Henrique Camara

    (Harvard Medical School)

  • Meghan Halpin

    (Harvard Medical School)

  • Niven R. Narain

    (BPGbio)

  • King-Wai Yau

    (Johns Hopkins University School of Medicine)

  • Matthew D. Lynes

    (Harvard Medical School
    MaineHealth Institute for Research)

  • Michael A. Kiebish

    (BPGbio)

  • Yu-Hua Tseng

    (Harvard Medical School
    Harvard University)

Abstract

Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose tissue which has extensive communication with other organs, particularly with the brain through the sympathetic nervous system (SNS). Our study reveals a new light-triggered crosstalk between adipose tissue and the hypothalamus. Direct blue-light exposure to subcutaneous white fat improves high-fat diet-induced metabolic abnormalities in an Opsin3-dependent manner. Metabolomic analysis shows that blue light increases circulating levels of histidine, which activates histaminergic neurons in the hypothalamus and stimulates brown adipose tissue (BAT) via SNS. Blocking central actions of histidine and denervating peripheral BAT blunts the effects of blue light. Human white adipocytes respond to direct blue light stimulation in a cell-autonomous manner, highlighting the translational relevance of this pathway. Together, these data demonstrate a light-responsive metabolic circuit involving adipose-hypothalamus communication, offering a potential strategy to alleviate obesity-induced metabolic abnormalities.

Suggested Citation

  • Tadataka Tsuji & Vladimir Tolstikov & Yang Zhang & Tian Lian Huang & Henrique Camara & Meghan Halpin & Niven R. Narain & King-Wai Yau & Matthew D. Lynes & Michael A. Kiebish & Yu-Hua Tseng, 2024. "Light-responsive adipose-hypothalamus axis controls metabolic regulation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50866-0
    DOI: 10.1038/s41467-024-50866-0
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    1. Margo P. Emont & Christopher Jacobs & Adam L. Essene & Deepti Pant & Danielle Tenen & Georgia Colleluori & Angelica Vincenzo & Anja M. Jørgensen & Hesam Dashti & Adam Stefek & Elizabeth McGonagle & So, 2022. "A single-cell atlas of human and mouse white adipose tissue," Nature, Nature, vol. 603(7903), pages 926-933, March.
    2. Kevin X. Zhang & Shane D’Souza & Brian A. Upton & Stace Kernodle & Shruti Vemaraju & Gowri Nayak & Kevin D. Gaitonde & Amanda L. Holt & Courtney D. Linne & April N. Smith & Nathan T. Petts & Matthew B, 2020. "Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons," Nature, Nature, vol. 585(7825), pages 420-425, September.
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