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A single-cell atlas of human and mouse white adipose tissue

Author

Listed:
  • Margo P. Emont

    (Beth Israel Deaconess Medical Center
    Broad Institute of MIT and Harvard)

  • Christopher Jacobs

    (Beth Israel Deaconess Medical Center
    Broad Institute of MIT and Harvard)

  • Adam L. Essene

    (Beth Israel Deaconess Medical Center)

  • Deepti Pant

    (Beth Israel Deaconess Medical Center)

  • Danielle Tenen

    (Beth Israel Deaconess Medical Center
    Broad Institute of MIT and Harvard)

  • Georgia Colleluori

    (Marche Polytechnic University)

  • Angelica Vincenzo

    (Marche Polytechnic University)

  • Anja M. Jørgensen

    (University of Copenhagen)

  • Hesam Dashti

    (Broad Institute of MIT and Harvard)

  • Adam Stefek

    (Broad Institute of MIT and Harvard)

  • Elizabeth McGonagle

    (Broad Institute of MIT and Harvard)

  • Sophie Strobel

    (Broad Institute of MIT and Harvard)

  • Samantha Laber

    (Broad Institute of MIT and Harvard)

  • Saaket Agrawal

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Gregory P. Westcott

    (Beth Israel Deaconess Medical Center)

  • Amrita Kar

    (Beth Israel Deaconess Medical Center
    Broad Institute of MIT and Harvard)

  • Molly L. Veregge

    (Beth Israel Deaconess Medical Center)

  • Anton Gulko

    (Beth Israel Deaconess Medical Center)

  • Harini Srinivasan

    (Beth Israel Deaconess Medical Center
    Broad Institute of MIT and Harvard)

  • Zachary Kramer

    (Beth Israel Deaconess Medical Center)

  • Eleanna Filippis

    (Diabetes and Metabolism)

  • Erin Merkel

    (Beth Israel Deaconess Medical Center)

  • Jennifer Ducie

    (Beth Israel Deaconess Medical Center)

  • Christopher G. Boyd

    (Beth Israel Deaconess Medical Center)

  • William Gourash

    (University of Pittsburgh Medical Center)

  • Anita Courcoulas

    (University of Pittsburgh Medical Center)

  • Samuel J. Lin

    (Beth Israel Deaconess Medical Center)

  • Bernard T. Lee

    (Beth Israel Deaconess Medical Center)

  • Donald Morris

    (Beth Israel Deaconess Medical Center)

  • Adam Tobias

    (Beth Israel Deaconess Medical Center)

  • Amit V. Khera

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Beth Israel Deaconess Medical Center)

  • Melina Claussnitzer

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Tune H. Pers

    (University of Copenhagen)

  • Antonio Giordano

    (Marche Polytechnic University)

  • Orr Ashenberg

    (Broad Institute of MIT and Harvard)

  • Aviv Regev

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology
    Genentech)

  • Linus T. Tsai

    (Beth Israel Deaconess Medical Center
    Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Evan D. Rosen

    (Beth Israel Deaconess Medical Center
    Broad Institute of MIT and Harvard
    Harvard Medical School)

Abstract

White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.

Suggested Citation

  • Margo P. Emont & Christopher Jacobs & Adam L. Essene & Deepti Pant & Danielle Tenen & Georgia Colleluori & Angelica Vincenzo & Anja M. Jørgensen & Hesam Dashti & Adam Stefek & Elizabeth McGonagle & So, 2022. "A single-cell atlas of human and mouse white adipose tissue," Nature, Nature, vol. 603(7903), pages 926-933, March.
    • Handle: RePEc:nat:nature:v:603:y:2022:i:7903:d:10.1038_s41586-022-04518-2
    DOI: 10.1038/s41586-022-04518-2
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    Citations

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    Cited by:

    1. Suyang Wu & Chen Qiu & Jiahao Ni & Wenli Guo & Jiyuan Song & Xingyin Yang & Yulin Sun & Yanjun Chen & Yunxia Zhu & Xiaoai Chang & Peng Sun & Chunxia Wang & Kai Li & Xiao Han, 2024. "M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Isabel Reinisch & Helene Michenthaler & Alba Sulaj & Elisabeth Moyschewitz & Jelena Krstic & Markus Galhuber & Ruonan Xu & Zina Riahi & Tongtong Wang & Nemanja Vujic & Melina Amor & Riccardo Zenezini , 2024. "Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. Sang Mun Han & Eun Seo Park & Jeu Park & Hahn Nahmgoong & Yoon Ha Choi & Jiyoung Oh & Kyung Min Yim & Won Taek Lee & Yun Kyung Lee & Yong Geun Jeon & Kyung Cheul Shin & Jin Young Huh & Sung Hee Choi &, 2023. "Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Aina Lluch & Jessica Latorre & Angela Serena-Maione & Isabel Espadas & Estefanía Caballano-Infantes & José M. Moreno-Navarrete & Núria Oliveras-Cañellas & Wifredo Ricart & María M. Malagón & Alejandro, 2023. "Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Matthew C. Sinton & Praveena R. G. Chandrasegaran & Paul Capewell & Anneli Cooper & Alex Girard & John Ogunsola & Georgia Perona-Wright & Dieudonné M Ngoyi & Nono Kuispond & Bruno Bucheton & Mamadou C, 2023. "IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    6. Lucas Massier & Jutta Jalkanen & Merve Elmastas & Jiawei Zhong & Tongtong Wang & Pamela A. Nono Nankam & Scott Frendo-Cumbo & Jesper Bäckdahl & Narmadha Subramanian & Takuya Sekine & Alastair G. Kerr , 2023. "An integrated single cell and spatial transcriptomic map of human white adipose tissue," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    7. Andreas Fønss Møller & Jesper Grud Skat Madsen, 2023. "JOINTLY: interpretable joint clustering of single-cell transcriptomes," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    8. Cheoljun Choi & Yujin L. Jeong & Koung-Min Park & Minji Kim & Sangseob Kim & Honghyun Jo & Sumin Lee & Heeseong Kim & Garam Choi & Yoon Ha Choi & Je Kyung Seong & Sik Namgoong & Yeonseok Chung & Young, 2024. "TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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