Author
Listed:
- Kevin X. Zhang
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine
University of Cincinnati, College of Medicine)
- Shane D’Souza
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine)
- Brian A. Upton
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine
University of Cincinnati, College of Medicine)
- Stace Kernodle
(University of Michigan, School of Public Health)
- Shruti Vemaraju
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center)
- Gowri Nayak
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center)
- Kevin D. Gaitonde
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine
University of Cincinnati, College of Medicine)
- Amanda L. Holt
(Yale University)
- Courtney D. Linne
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine
University of Cincinnati, College of Medicine)
- April N. Smith
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center)
- Nathan T. Petts
(Cincinnati Children’s Hospital Medical Center)
- Matthew Batie
(Cincinnati Children’s Hospital Medical Center)
- Rajib Mukherjee
(Cincinnati Children’s Hospital Medical Center)
- Durgesh Tiwari
(Cincinnati Children’s Hospital Medical Center)
- Ethan D. Buhr
(University of Washington Medical School)
- Russell N. Gelder
(University of Washington Medical School
University of Washington Medical School
University of Washington Medical School)
- Christina Gross
(Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine)
- Alison Sweeney
(Yale University)
- Joan Sanchez-Gurmaches
(Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine
Cincinnati Children’s Hospital Medical Center)
- Randy J. Seeley
(University of Michigan, School of Public Health
University of Michigan, School of Public Health)
- Richard A. Lang
(Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center
Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine)
Abstract
The opsin family of G-protein-coupled receptors are used as light detectors in animals. Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible violet light1,2. In mice, OPN5 is a known photoreceptor in the retina3 and skin4 but is also expressed in the hypothalamic preoptic area (POA)5. Here we describe a light-sensing pathway in which POA neurons that express Opn5 regulate thermogenesis in brown adipose tissue (BAT). We show that Opn5 is expressed in glutamatergic warm-sensing POA neurons that receive synaptic input from several thermoregulatory nuclei. We further show that Opn5 POA neurons project to BAT and decrease its activity under chemogenetic stimulation. Opn5-null mice show overactive BAT, increased body temperature, and exaggerated thermogenesis when cold-challenged. Moreover, violet photostimulation during cold exposure acutely suppresses BAT temperature in wild-type mice but not in Opn5-null mice. Direct measurements of intracellular cAMP ex vivo show that Opn5 POA neurons increase cAMP when stimulated with violet light. This analysis thus identifies a violet light-sensitive deep brain photoreceptor that normally suppresses BAT thermogenesis.
Suggested Citation
Kevin X. Zhang & Shane D’Souza & Brian A. Upton & Stace Kernodle & Shruti Vemaraju & Gowri Nayak & Kevin D. Gaitonde & Amanda L. Holt & Courtney D. Linne & April N. Smith & Nathan T. Petts & Matthew B, 2020.
"Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons,"
Nature, Nature, vol. 585(7825), pages 420-425, September.
Handle:
RePEc:nat:nature:v:585:y:2020:i:7825:d:10.1038_s41586-020-2683-0
DOI: 10.1038/s41586-020-2683-0
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Cited by:
- Tadataka Tsuji & Vladimir Tolstikov & Yang Zhang & Tian Lian Huang & Henrique Camara & Meghan Halpin & Niven R. Narain & King-Wai Yau & Matthew D. Lynes & Michael A. Kiebish & Yu-Hua Tseng, 2024.
"Light-responsive adipose-hypothalamus axis controls metabolic regulation,"
Nature Communications, Nature, vol. 15(1), pages 1-19, December.
- Ruina Wang & Lei Xiao & Jianbo Pan & Guangsen Bao & Yunmei Zhu & Di Zhu & Jun Wang & Chengfeng Pei & Qinfeng Ma & Xian Fu & Ziruoyu Wang & Mengdi Zhu & Guoxiang Wang & Ling Gong & Qiuping Tong & Min J, 2023.
"Natural product P57 induces hypothermia through targeting pyridoxal kinase,"
Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Wen Z. Yang & Hengchang Xie & Xiaosa Du & Qian Zhou & Yan Xiao & Zhengdong Zhao & Xiaoning Jia & Jianhui Xu & Wen Zhang & Shuang Cai & Zhangjie Li & Xin Fu & Rong Hua & Junhao Cai & Shuang Chang & Jin, 2023.
"A parabrachial-hypothalamic parallel circuit governs cold defense in mice,"
Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Ahmed Wagdi & Daniela Malan & Udhayabhaskar Sathyanarayanan & Janosch S. Beauchamp & Markus Vogt & David Zipf & Thomas Beiert & Berivan Mansuroglu & Vanessa Dusend & Mark Meininghaus & Linn Schneider , 2022.
"Selective optogenetic control of Gq signaling using human Neuropsin,"
Nature Communications, Nature, vol. 13(1), pages 1-18, December.
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