Author
Listed:
- Angeliki Damilou
(University of Zurich
University of Zürich
Neuroscience Center Zurich)
- Linbi Cai
(University of Zurich
Neuroscience Center Zurich)
- Ali Özgür Argunşah
(University of Zurich
Neuroscience Center Zurich)
- Shuting Han
(Neuroscience Center Zurich
University of Zurich)
- George Kanatouris
(University of Zurich
Neuroscience Center Zurich)
- Maria Karatsoli
(University of Zurich
University of Zürich
Neuroscience Center Zurich)
- Olivia Hanley
(University of Zurich
Neuroscience Center Zurich)
- Lorenzo Gesuita
(University of Zurich
Neuroscience Center Zurich)
- Sepp Kollmorgen
(University of Zürich)
- Fritjof Helmchen
(University of Zürich
Neuroscience Center Zurich
University of Zurich)
- Theofanis Karayannis
(University of Zurich
University of Zürich
Neuroscience Center Zurich)
Abstract
The role of developmental cell death in the formation of brain circuits is not well understood. Cajal-Retzius cells constitute a major transient neuronal population in the mammalian neocortex, which largely disappears at the time of postnatal somatosensory maturation. In this study, we used mouse genetics, anatomical, functional, and behavioral approaches to explore the impact of the early postnatal death of Cajal-Retzius cells in the maturation of the cortical circuit. We find that before their death, Cajal-Retzius cells mainly receive inputs from layer 1 neurons, which can only develop their mature connectivity onto layer 2/3 pyramidal cells after Cajal-Retzius cells disappear. This developmental connectivity progression from layer 1 GABAergic to layer 2/3 pyramidal cells regulates sensory-driven inhibition within, and more so, across cortical columns. Here we show that Cajal-Retzius cell death prevention leads to layer 2/3 hyper-excitability, delayed learning and reduced performance in a multi-whisker-dependent texture discrimination task.
Suggested Citation
Angeliki Damilou & Linbi Cai & Ali Özgür Argunşah & Shuting Han & George Kanatouris & Maria Karatsoli & Olivia Hanley & Lorenzo Gesuita & Sepp Kollmorgen & Fritjof Helmchen & Theofanis Karayannis, 2024.
"Developmental Cajal-Retzius cell death contributes to the maturation of layer 1 cortical inhibition and somatosensory processing,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
Handle:
RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50658-6
DOI: 10.1038/s41467-024-50658-6
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