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Pyramidal cell regulation of interneuron survival sculpts cortical networks

Author

Listed:
  • Fong Kuan Wong

    (King’s College London
    King’s College London)

  • Kinga Bercsenyi

    (King’s College London
    King’s College London)

  • Varun Sreenivasan

    (King’s College London
    King’s College London)

  • Adrián Portalés

    (King’s College London
    King’s College London)

  • Marian Fernández-Otero

    (King’s College London
    King’s College London)

  • Oscar Marín

    (King’s College London
    King’s College London)

Abstract

Complex neuronal circuitries such as those found in the mammalian cerebral cortex have evolved as balanced networks of excitatory and inhibitory neurons. Although the establishment of appropriate numbers of these cells is essential for brain function and behaviour, our understanding of this fundamental process is limited. Here we show that the survival of interneurons in mice depends on the activity of pyramidal cells in a critical window of postnatal development, during which excitatory synaptic input to individual interneurons predicts their survival or death. Pyramidal cells regulate interneuron survival through the negative modulation of PTEN signalling, which effectively drives interneuron cell death during this period. Our findings indicate that activity-dependent mechanisms dynamically adjust the number of inhibitory cells in nascent local cortical circuits, ultimately establishing the appropriate proportions of excitatory and inhibitory neurons in the cerebral cortex.

Suggested Citation

  • Fong Kuan Wong & Kinga Bercsenyi & Varun Sreenivasan & Adrián Portalés & Marian Fernández-Otero & Oscar Marín, 2018. "Pyramidal cell regulation of interneuron survival sculpts cortical networks," Nature, Nature, vol. 557(7707), pages 668-673, May.
  • Handle: RePEc:nat:nature:v:557:y:2018:i:7707:d:10.1038_s41586-018-0139-6
    DOI: 10.1038/s41586-018-0139-6
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    Cited by:

    1. Angeliki Damilou & Linbi Cai & Ali Özgür Argunşah & Shuting Han & George Kanatouris & Maria Karatsoli & Olivia Hanley & Lorenzo Gesuita & Sepp Kollmorgen & Fritjof Helmchen & Theofanis Karayannis, 2024. "Developmental Cajal-Retzius cell death contributes to the maturation of layer 1 cortical inhibition and somatosensory processing," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Li-Pao Fang & Na Zhao & Laura C. Caudal & Hsin-Fang Chang & Renping Zhao & Ching-Hsin Lin & Nadine Hainz & Carola Meier & Bernhard Bettler & Wenhui Huang & Anja Scheller & Frank Kirchhoff & Xianshu Ba, 2022. "Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Deepanjali Dwivedi & Dimitri Dumontier & Mia Sherer & Sherry Lin & Andrea M. C. Mirow & Yanjie Qiu & Qing Xu & Samuel A. Liebman & Djeckby Joseph & Sandeep R. Datta & Gord Fishell & Gabrielle Pouchelo, 2024. "Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Luke F. Nunnelly & Melissa Campbell & Dylan I. Lee & Patrick Dummer & Guoqiang Gu & Vilas Menon & Edmund Au, 2022. "St18 specifies globus pallidus projection neuron identity in MGE lineage," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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