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St18 specifies globus pallidus projection neuron identity in MGE lineage

Author

Listed:
  • Luke F. Nunnelly

    (Columbia University Irving Medical Center)

  • Melissa Campbell

    (Columbia University Irving Medical Center)

  • Dylan I. Lee

    (Columbia University Irving Medical Center)

  • Patrick Dummer

    (Columbia University Irving Medical Center)

  • Guoqiang Gu

    (Vanderbilt University School of Medicine)

  • Vilas Menon

    (Columbia University Irving Medical Center)

  • Edmund Au

    (Columbia University Irving Medical Center
    Columbia University Irving Medical Center
    Columbia University Irving Medical Center)

Abstract

The medial ganglionic eminence (MGE) produces both locally-projecting interneurons, which migrate long distances to structures such as the cortex as well as projection neurons that occupy subcortical nuclei. Little is known about what regulates the migratory behavior and axonal projections of these two broad classes of neurons. We find that St18 regulates the migration and morphology of MGE neurons in vitro. Further, genetic loss-of-function of St18 in mice reveals a reduction in projection neurons of the globus pallidus pars externa. St18 functions by influencing cell fate in MGE lineages as we observe a large expansion of nascent cortical interneurons at the expense of putative GPe neurons in St18 null embryos. Downstream of St18, we identified Cbx7, a component of Polycomb repressor complex 1, and find that it is essential for projection neuron-like migration but not morphology. Thus, we identify St18 as a key regulator of projection neuron vs. interneuron identity.

Suggested Citation

  • Luke F. Nunnelly & Melissa Campbell & Dylan I. Lee & Patrick Dummer & Guoqiang Gu & Vilas Menon & Edmund Au, 2022. "St18 specifies globus pallidus projection neuron identity in MGE lineage," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35518-5
    DOI: 10.1038/s41467-022-35518-5
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    References listed on IDEAS

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    1. Fong Kuan Wong & Kinga Bercsenyi & Varun Sreenivasan & Adrián Portalés & Marian Fernández-Otero & Oscar Marín, 2018. "Pyramidal cell regulation of interneuron survival sculpts cortical networks," Nature, Nature, vol. 557(7707), pages 668-673, May.
    2. Ruchi Malik & Emily Ling-Lin Pai & Anna N Rubin & April M Stafford & Kartik Angara & Petros Minasi & John L. Rubenstein & Vikaas S Sohal & Daniel Vogt, 2019. "Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    3. Derek G. Southwell & Mercedes F. Paredes & Rui P. Galvao & Daniel L. Jones & Robert C. Froemke & Joy Y. Sebe & Clara Alfaro-Cervello & Yunshuo Tang & Jose M. Garcia-Verdugo & John L. Rubenstein & Scot, 2012. "Intrinsically determined cell death of developing cortical interneurons," Nature, Nature, vol. 491(7422), pages 109-113, November.
    4. Julian Ik-Tsen Heng & Laurent Nguyen & Diogo S. Castro & Céline Zimmer & Hendrik Wildner & Olivier Armant & Dorota Skowronska-Krawczyk & Francesco Bedogni & Jean-Marc Matter & Robert Hevner & François, 2008. "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2," Nature, Nature, vol. 455(7209), pages 114-118, September.
    5. Moritz Mall & Michael S. Kareta & Soham Chanda & Henrik Ahlenius & Nicholas Perotti & Bo Zhou & Sarah D. Grieder & Xuecai Ge & Sienna Drake & Cheen Euong Ang & Brandon M. Walker & Thomas Vierbuchen & , 2017. "Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates," Nature, Nature, vol. 544(7649), pages 245-249, April.
    6. Christian Mayer & Christoph Hafemeister & Rachel C. Bandler & Robert Machold & Renata Batista Brito & Xavier Jaglin & Kathryn Allaway & Andrew Butler & Gord Fishell & Rahul Satija, 2018. "Developmental diversification of cortical inhibitory interneurons," Nature, Nature, vol. 555(7697), pages 457-462, March.
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