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Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias

Author

Listed:
  • Chenlu Wang

    (Wuhan University)

  • Liping Zhou

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Chengzhe Liu

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Jiaming Qiao

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Xinrui Han

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Luyang Wang

    (Wuhan University)

  • Yaxi Liu

    (Wuhan University)

  • Bi Xu

    (Wuhan University)

  • Qinfang Qiu

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Zizhuo Zhang

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Jiale Wang

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Xiaoya Zhou

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Mengqi Zeng

    (Wuhan University)

  • Lilei Yu

    (Renmin Hospital of Wuhan University
    Hubei Key Laboratory of Autonomic Nervous System Modulation
    Cardiac Autonomic Nervous System Research Center of Wuhan University
    Hubei Key Laboratory of Cardiology)

  • Lei Fu

    (Wuhan University
    Wuhan University
    Renmin Hospital of Wuhan University
    Wuhan University)

Abstract

Autonomic nervous system disorders play a pivotal role in the pathophysiology of cardiovascular diseases. Regulating it is essential for preventing and treating acute ventricular arrhythmias (VAs). Photothermal neuromodulation is a nonimplanted technique, but the response temperature ranges of transient receptor potential vanilloid 1 (TRPV1) and TWIK-related K+ Channel 1 (TREK1) exhibit differences while being closely aligned, and the acute nature of VAs require that it must be rapid and precise. However, the low photothermal conversion efficiency (PCE) still poses limitations in achieving rapid and precise treatment. Here, we achieve a nearly perfect blackbody absorption and a high PCE in the second near infrared (NIR-II) window (73.7% at 1064 nm) via a Pt nanoparticle shell (PtNP-shell). By precisely manipulating the photothermal effect, we successfully achieve rapid and precise multimodal neuromodulation encompassing neural activation (41.0–42.9 °C) and inhibition (45.0–46.9 °C) in a male canine model. The NIR-II photothermal modulation additionally achieves multimodal reversible autonomic modulation and confers protection against acute VAs associated with myocardial ischemia and reperfusion injury in interventional therapy.

Suggested Citation

  • Chenlu Wang & Liping Zhou & Chengzhe Liu & Jiaming Qiao & Xinrui Han & Luyang Wang & Yaxi Liu & Bi Xu & Qinfang Qiu & Zizhuo Zhang & Jiale Wang & Xiaoya Zhou & Mengqi Zeng & Lilei Yu & Lei Fu, 2024. "Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50557-w
    DOI: 10.1038/s41467-024-50557-w
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    References listed on IDEAS

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    1. Colleen Jackson & Graham T. Smith & David W. Inwood & Andrew S. Leach & Penny S. Whalley & Mauro Callisti & Tomas Polcar & Andrea E. Russell & Pieter Levecque & Denis Kramer, 2017. "Electronic metal-support interaction enhanced oxygen reduction activity and stability of boron carbide supported platinum," Nature Communications, Nature, vol. 8(1), pages 1-11, August.
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