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Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Author

Listed:
  • Alfred Pozarickij

    (University of Oxford)

  • Wei Gan

    (University of Oxford
    Old Road Campus)

  • Kuang Lin

    (University of Oxford)

  • Robert Clarke

    (University of Oxford)

  • Zammy Fairhurst-Hunter

    (University of Oxford)

  • Masaru Koido

    (The University of Tokyo)

  • Masahiro Kanai

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Yukinori Okada

    (Osaka University Graduate School of Medicine
    University of Tokyo
    RIKEN Center for Integrative Medical Sciences
    Osaka University)

  • Yoichiro Kamatani

    (The University of Tokyo)

  • Derrick Bennett

    (University of Oxford)

  • Huaidong Du

    (University of Oxford)

  • Yiping Chen

    (University of Oxford)

  • Ling Yang

    (University of Oxford)

  • Daniel Avery

    (University of Oxford)

  • Yu Guo

    (Chinese Academy of Medical Sciences)

  • Min Yu

    (Zhejiang CDC)

  • Canqing Yu

    (Peking University
    Peking University Center for Public Health and Epidemic Preparedness and Response
    Ministry of Education)

  • Dan Schmidt Valle

    (University of Oxford)

  • Jun Lv

    (Peking University
    Peking University Center for Public Health and Epidemic Preparedness and Response
    Ministry of Education)

  • Junshi Chen

    (China National Center For Food Safety Risk Assessment)

  • Richard Peto

    (University of Oxford)

  • Rory Collins

    (University of Oxford)

  • Liming Li

    (Peking University
    Peking University Center for Public Health and Epidemic Preparedness and Response
    Ministry of Education)

  • Zhengming Chen

    (University of Oxford)

  • Iona Y. Millwood

    (University of Oxford)

  • Robin G. Walters

    (University of Oxford)

Abstract

Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated that BP traits contribute differently to the causal associations of BP with CVD. In particular, only pulse pressure was independently causally associated with carotid plaque. These findings reinforce the need for studies in diverse populations to understand the genetic determinants of BP traits and their roles in disease risk.

Suggested Citation

  • Alfred Pozarickij & Wei Gan & Kuang Lin & Robert Clarke & Zammy Fairhurst-Hunter & Masaru Koido & Masahiro Kanai & Yukinori Okada & Yoichiro Kamatani & Derrick Bennett & Huaidong Du & Yiping Chen & Li, 2024. "Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50297-x
    DOI: 10.1038/s41467-024-50297-x
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    References listed on IDEAS

    as
    1. Mengying Wang & Wenyong Li & Ren Zhou & Siyue Wang & Hongchen Zheng & Jin Jiang & Shengfeng Wang & Canqing Yu & Wenjing Gao & Jun Lv & Tao Wu & Weihua Cao & Yonghua Hu & Liming Li & John S. Ji, 2020. "The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People," IJERPH, MDPI, vol. 17(8), pages 1-11, April.
    2. Fumihiko Takeuchi & Masato Akiyama & Nana Matoba & Tomohiro Katsuya & Masahiro Nakatochi & Yasuharu Tabara & Akira Narita & Woei-Yuh Saw & Sanghoon Moon & Cassandra N. Spracklen & Jin-Fang Chai & Youn, 2018. "Interethnic analyses of blood pressure loci in populations of East Asian and European descent," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    3. Huwenbo Shi & Steven Gazal & Masahiro Kanai & Evan M. Koch & Armin P. Schoech & Katherine M. Siewert & Samuel S. Kim & Yang Luo & Tiffany Amariuta & Hailiang Huang & Yukinori Okada & Soumya Raychaudhu, 2021. "Population-specific causal disease effect sizes in functionally important regions impacted by selection," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
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