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Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Author

Listed:
  • Fumihiko Takeuchi

    (National Center for Global Health and Medicine
    National Center for Global Health and Medicine)

  • Masato Akiyama

    (RIKEN Center for Integrative Medical Sciences)

  • Nana Matoba

    (RIKEN Center for Integrative Medical Sciences)

  • Tomohiro Katsuya

    (Osaka University Graduate School of Medicine
    Osaka University Graduate School of Medicine)

  • Masahiro Nakatochi

    (Nagoya University Hospital)

  • Yasuharu Tabara

    (Kyoto University Graduate School of Medicine)

  • Akira Narita

    (Tohoku University)

  • Woei-Yuh Saw

    (National University of Singapore and National University Health System
    National University of Singapore)

  • Sanghoon Moon

    (National Institute of Health)

  • Cassandra N. Spracklen

    (University of North Carolina)

  • Jin-Fang Chai

    (National University of Singapore and National University Health System)

  • Young-Jin Kim

    (National Institute of Health)

  • Liang Zhang

    (Singapore National Eye Centre)

  • Chaolong Wang

    (Agency for Science, Technology and Research
    Duke-NUS Medical School
    Huazhong University of Science and Technology)

  • Huaixing Li

    (University of the Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Honglan Li

    (Shanghai Jiaotong University School of Medicine)

  • Jer-Yuarn Wu

    (Academia Sinica
    China Medical University)

  • Rajkumar Dorajoo

    (Agency for Science, Technology and Research)

  • Jovia L. Nierenberg

    (Tulane University School of Public Health and Tropical Medicine)

  • Ya Xing Wang

    (Capital Medical University)

  • Jing He

    (Vanderbilt University Medical Center)

  • Derrick A. Bennett

    (University of Oxford)

  • Atsushi Takahashi

    (RIKEN Center for Integrative Medical Sciences
    National Cerebral and Cardiovascular Center)

  • Yukihide Momozawa

    (RIKEN Center for Integrative Medical Sciences)

  • Makoto Hirata

    (The University of Tokyo)

  • Koichi Matsuda

    (The University of Tokyo)

  • Hiromi Rakugi

    (Osaka University Graduate School of Medicine)

  • Eitaro Nakashima

    (Nagoya University Graduate School of Medicine
    Chubu Rosai Hospital)

  • Masato Isono

    (National Center for Global Health and Medicine)

  • Matsuyuki Shirota

    (Tohoku University)

  • Atsushi Hozawa

    (Tohoku University)

  • Sahoko Ichihara

    (Jichi Medical University School of Medicine)

  • Tatsuaki Matsubara

    (Aichi Gakuin University)

  • Ken Yamamoto

    (Kurume University School of Medicine)

  • Katsuhiko Kohara

    (Ehime University)

  • Michiya Igase

    (Ehime University Graduate School of Medicine)

  • Sohee Han

    (National Institute of Health)

  • Penny Gordon-Larsen

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Wei Huang

    (Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI))

  • Nanette R. Lee

    (University of San Carlos
    University of San Carlos)

  • Linda S. Adair

    (University of North Carolina at Chapel Hill
    University of North Carolina at Chapel Hill)

  • Mi Yeong Hwang

    (National Institute of Health)

  • Juyoung Lee

    (National Institute of Health)

  • Miao Li Chee

    (Singapore National Eye Centre)

  • Charumathi Sabanayagam

    (Singapore National Eye Centre
    Duke-NUS Medical School
    National University of Singapore)

  • Wanting Zhao

    (Singapore National Eye Centre
    Duke-NUS Medical School)

  • Jianjun Liu

    (Agency for Science, Technology and Research
    National University of Singapore)

  • Dermot F. Reilly

    (Merck Sharp Dohme Corp)

  • Liang Sun

    (University of the Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Shaofeng Huo

    (University of the Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Todd L. Edwards

    (Vanderbilt University Medical Center)

  • Jirong Long

    (Vanderbilt University Medical Center)

  • Li-Ching Chang

    (Academia Sinica)

  • Chien-Hsiun Chen

    (Academia Sinica)

  • Jian-Min Yuan

    (University of Pittsburgh
    University of Pittsburgh)

  • Woon-Puay Koh

    (National University of Singapore and National University Health System
    Duke-NUS Medical School)

  • Yechiel Friedlander

    (Hebrew University-Hadassah Braun School of Public Health)

  • Tanika N. Kelly

    (Tulane University School of Public Health and Tropical Medicine)

  • Wen Wei

    (Capital Medical University)

  • Liang Xu

    (Capital Medical University)

  • Hui Cai

    (Vanderbilt University Medical Center)

  • Yong-Bing Xiang

    (Shanghai Jiaotong University School of Medicine)

  • Kuang Lin

    (University of Oxford)

  • Robert Clarke

    (University of Oxford)

  • Robin G. Walters

    (University of Oxford)

  • Iona Y. Millwood

    (University of Oxford
    University of Oxford)

  • Liming Li

    (Chinese Academy of Medical Sciences
    Peking University)

  • John C. Chambers

    (Imperial College London)

  • Jaspal S. Kooner

    (Imperial College London)

  • Paul Elliott

    (Imperial College London
    Imperial College London
    UK-Dementia Research Institute at Imperial College London
    National Institute for Health Research (NIHR) Health Protection Research Unit on Health Impacts of Environmental Hazards)

  • Pim van der Harst

    (University Medical Center Groningen)

  • Zhengming Chen

    (University of Oxford)

  • Makoto Sasaki

    (Iwate Tohoku Medical Megabank Organization)

  • Xiao-Ou Shu

    (Vanderbilt University Medical Center)

  • Jost B. Jonas

    (Capital Medical University
    University Heidelberg, Germany)

  • Jiang He

    (Tulane University School of Public Health and Tropical Medicine
    Tulane University School of Medicine)

  • Chew-Kiat Heng

    (National University of Singapore
    National University Health System)

  • Yuan-Tsong Chen

    (Academia Sinica)

  • Wei Zheng

    (Vanderbilt University Medical Center)

  • Xu Lin

    (University of the Chinese Academy of Sciences, Chinese Academy of Sciences)

  • Yik-Ying Teo

    (National University of Singapore and National University Health System
    National University of Singapore
    National University of Singapore)

  • E-Shyong Tai

    (National University of Singapore and National University Health System
    Duke-NUS Medical School
    National University of Singapore)

  • Ching-Yu Cheng

    (Singapore National Eye Centre
    Duke-NUS Medical School
    National University of Singapore)

  • Tien Yin Wong

    (Singapore National Eye Centre
    Duke-NUS Medical School
    National University of Singapore)

  • Xueling Sim

    (National University of Singapore and National University Health System)

  • Karen L. Mohlke

    (University of North Carolina)

  • Masayuki Yamamoto

    (Tohoku University)

  • Bong-Jo Kim

    (National Institute of Health)

  • Tetsuro Miki

    (Ehime University Graduate School of Medicine)

  • Toru Nabika

    (Shimane University Faculty of Medicine)

  • Mitsuhiro Yokota

    (Aichi Gakuin University)

  • Yoichiro Kamatani

    (RIKEN Center for Integrative Medical Sciences
    Kyoto University Graduate School of Medicine)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • Norihiro Kato

    (National Center for Global Health and Medicine
    National Center for Global Health and Medicine)

Abstract

Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

Suggested Citation

  • Fumihiko Takeuchi & Masato Akiyama & Nana Matoba & Tomohiro Katsuya & Masahiro Nakatochi & Yasuharu Tabara & Akira Narita & Woei-Yuh Saw & Sanghoon Moon & Cassandra N. Spracklen & Jin-Fang Chai & Youn, 2018. "Interethnic analyses of blood pressure loci in populations of East Asian and European descent," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07345-0
    DOI: 10.1038/s41467-018-07345-0
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    Cited by:

    1. Xinyuan Zhang & Anastasia M. Lucas & Yogasudha Veturi & Theodore G. Drivas & William P. Bone & Anurag Verma & Wendy K. Chung & David Crosslin & Joshua C. Denny & Scott Hebbring & Gail P. Jarvik & Ifti, 2022. "Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Edith Le Floch & Teresa Cosentino & Casper K. Larsen & Felix Beuschlein & Martin Reincke & Laurence Amar & Gian-Paolo Rossi & Kelly De Sousa & Stéphanie Baron & Sophie Chantalat & Benjamin Saintpierre, 2022. "Identification of risk loci for primary aldosteronism in genome-wide association studies," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Alfred Pozarickij & Wei Gan & Kuang Lin & Robert Clarke & Zammy Fairhurst-Hunter & Masaru Koido & Masahiro Kanai & Yukinori Okada & Yoichiro Kamatani & Derrick Bennett & Huaidong Du & Yiping Chen & Li, 2024. "Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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