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Protective alleles and precision healthcare in crewed spaceflight

Author

Listed:
  • Lindsay A. Rutter

    (University of Tsukuba
    Institute of Medicine, University of Tsukuba
    University of Glasgow)

  • Matthew J. MacKay

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

  • Henry Cope

    (University of Nottingham)

  • Nathaniel J. Szewczyk

    (University of Nottingham
    Ohio University)

  • JangKeun Kim

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Eliah Overbey

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Braden T. Tierney

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Masafumi Muratani

    (University of Tsukuba
    Institute of Medicine, University of Tsukuba)

  • Ben Lamm

    (Unit #155 Austin)

  • Daniela Bezdan

    (University of Tübingen
    University of Tübingen
    Yuri GmbH)

  • Amber M. Paul

    (Department of Human Factors and Behavioral Neurobiology)

  • Michael A. Schmidt

    (Sovaris Aerospace
    Advanced Pattern Analysis & Human Performance Group)

  • George M. Church

    (GC Therapeutics Inc
    Harvard Medical School
    Harvard University)

  • Stefania Giacomello

    (KTH Royal Institute of Technology)

  • Christopher E. Mason

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine
    Harvard University)

Abstract

Common and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health. Although some technical and ethical challenges remain, research into these protective mechanisms could translate into improved nutrition, exercise, and health recommendations for crew members during deep space missions.

Suggested Citation

  • Lindsay A. Rutter & Matthew J. MacKay & Henry Cope & Nathaniel J. Szewczyk & JangKeun Kim & Eliah Overbey & Braden T. Tierney & Masafumi Muratani & Ben Lamm & Daniela Bezdan & Amber M. Paul & Michael , 2024. "Protective alleles and precision healthcare in crewed spaceflight," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49423-6
    DOI: 10.1038/s41467-024-49423-6
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    References listed on IDEAS

    as
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