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Astronaut omics and the impact of space on the human body at scale

Author

Listed:
  • Lindsay A. Rutter

    (University of Tsukuba
    University of Tsukuba
    University of Glasgow)

  • Henry Cope

    (University of Nottingham)

  • Matthew J. MacKay

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

  • Raúl Herranz

    (Centro de Investigaciones Biológicas “Margarita Salas” (CSIC))

  • Saswati Das

    (Atal Bihari Vajpayee Institute of Medical Sciences & Dr. Ram Manohar Lohia Hospital)

  • Sergey A. Ponomarev

    (Russian Academy of Sciences)

  • Sylvain V. Costes

    (NASA Ames Research Center)

  • Amber M. Paul

    (Department of Human Factors and Behavioral Neurobiology)

  • Richard Barker

    (University of Wisconsin-Madison)

  • Deanne M. Taylor

    (The Children’s Hospital of Philadelphia
    University of Pennsylvania)

  • Daniela Bezdan

    (University of Tübingen
    University of Tübingen
    yuri GmbH)

  • Nathaniel J. Szewczyk

    (University of Nottingham
    Ohio University)

  • Masafumi Muratani

    (University of Tsukuba
    University of Tsukuba)

  • Christopher E. Mason

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

  • Stefania Giacomello

    (KTH Royal Institute of Technology)

Abstract

Future multi-year crewed planetary missions will motivate advances in aerospace nutrition and telehealth. On Earth, the Human Cell Atlas project aims to spatially map all cell types in the human body. Here, we propose that a parallel Human Cell Space Atlas could serve as an openly available, global resource for space life science research. As humanity becomes increasingly spacefaring, high-resolution omics on orbit could permit an advent of precision spaceflight healthcare. Alongside the scientific potential, we consider the complex ethical, cultural, and legal challenges intrinsic to the human space omics discipline, and how philosophical frameworks may benefit from international perspectives.

Suggested Citation

  • Lindsay A. Rutter & Henry Cope & Matthew J. MacKay & Raúl Herranz & Saswati Das & Sergey A. Ponomarev & Sylvain V. Costes & Amber M. Paul & Richard Barker & Deanne M. Taylor & Daniela Bezdan & Nathani, 2024. "Astronaut omics and the impact of space on the human body at scale," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47237-0
    DOI: 10.1038/s41467-024-47237-0
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    References listed on IDEAS

    as
    1. Orit Rozenblatt-Rosen & Michael J. T. Stubbington & Aviv Regev & Sarah A. Teichmann, 2017. "The Human Cell Atlas: from vision to reality," Nature, Nature, vol. 550(7677), pages 451-453, October.
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    Cited by:

    1. Lindsay A. Rutter & Matthew J. MacKay & Henry Cope & Nathaniel J. Szewczyk & JangKeun Kim & Eliah Overbey & Braden T. Tierney & Masafumi Muratani & Ben Lamm & Daniela Bezdan & Amber M. Paul & Michael , 2024. "Protective alleles and precision healthcare in crewed spaceflight," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Eliah G. Overbey & Krista Ryon & JangKeun Kim & Braden T. Tierney & Remi Klotz & Veronica Ortiz & Sean Mullane & Julian C. Schmidt & Matthew MacKay & Namita Damle & Deena Najjar & Irina Matei & Laura , 2024. "Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Kirill Grigorev & Theodore M. Nelson & Eliah G. Overbey & Nadia Houerbi & JangKeun Kim & Deena Najjar & Namita Damle & Evan E. Afshin & Krista A. Ryon & Jean Thierry-Mieg & Danielle Thierry-Mieg & Ari, 2024. "Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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