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The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

Author

Listed:
  • Eliah G. Overbey

    (Weill Cornell Medicine
    Weill Cornell Medicine
    BioAstra Inc.
    University of Austin)

  • JangKeun Kim

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Braden T. Tierney

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Jiwoon Park

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Nadia Houerbi

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Alexander G. Lucaci

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Sebastian Garcia Medina

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Namita Damle

    (Weill Cornell Medicine)

  • Deena Najjar

    (Albert Einstein College of Medicine)

  • Kirill Grigorev

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Evan E. Afshin

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Krista A. Ryon

    (Weill Cornell Medicine)

  • Karolina Sienkiewicz

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Laura Patras

    (Weill Cornell Medicine
    Babes-Bolyai University)

  • Remi Klotz

    (University of Southern California)

  • Veronica Ortiz

    (University of Southern California)

  • Matthew MacKay

    (Weill Cornell Medicine)

  • Annalise Schweickart

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Christopher R. Chin

    (Weill Cornell Medicine)

  • Maria A. Sierra

    (Weill Cornell Medicine)

  • Matias F. Valenzuela

    (Buck Institute for Research on Aging)

  • Ezequiel Dantas

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Theodore M. Nelson

    (Columbia University Irving Medical Center)

  • Egle Cekanaviciute

    (NASA Ames Research Center)

  • Gabriel Deards

    (Weill Cornell Medicine)

  • Jonathan Foox

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • S. Anand Narayanan

    (Florida State University)

  • Caleb M. Schmidt

    (Sovaris Aerospace
    Advanced Pattern Analysis and Human Performance Group
    Colorado State University)

  • Michael A. Schmidt

    (Sovaris Aerospace
    Advanced Pattern Analysis and Human Performance Group)

  • Julian C. Schmidt

    (Sovaris Aerospace
    Advanced Pattern Analysis and Human Performance Group)

  • Sean Mullane

    (Space Exploration Technologies Corporation (SpaceX))

  • Seth Stravers Tigchelaar

    (Space Exploration Technologies Corporation (SpaceX))

  • Steven Levitte

    (Space Exploration Technologies Corporation (SpaceX)
    Stanford University)

  • Craig Westover

    (Weill Cornell Medicine)

  • Chandrima Bhattacharya

    (Weill Cornell Medicine)

  • Serena Lucotti

    (Weill Cornell Medicine)

  • Jeremy Wain Hirschberg

    (Weill Cornell Medicine)

  • Jacqueline Proszynski

    (Weill Cornell Medicine)

  • Marissa Burke

    (Weill Cornell Medicine
    Houston Methodist Research Institute)

  • Ashley S. Kleinman

    (Weill Cornell Medicine)

  • Daniel J. Butler

    (Weill Cornell Medicine)

  • Conor Loy

    (Cornell University)

  • Omary Mzava

    (Cornell University)

  • Joan Lenz

    (Cornell University)

  • Doru Paul

    (Weill Cornell Medicine)

  • Christopher Mozsary

    (Weill Cornell Medicine)

  • Lauren M. Sanders

    (NASA Ames Research Center)

  • Lynn E. Taylor

    (Colorado State University)

  • Chintan O. Patel

    (TrialX Inc.)

  • Sharib A. Khan

    (TrialX Inc.)

  • Mir Suhail Mohamad

    (TrialX Inc.)

  • Syed Gufran Ahmad Byhaqui

    (TrialX Inc.)

  • Burhan Aslam

    (TrialX Inc.)

  • Aaron S. Gajadhar

    (Seer Inc.)

  • Lucy Williamson

    (Seer Inc.)

  • Purvi Tandel

    (Seer Inc.)

  • Qiu Yang

    (Seer Inc.)

  • Jessica Chu

    (Seer Inc.)

  • Ryan W. Benz

    (Seer Inc.)

  • Asim Siddiqui

    (Seer Inc.)

  • Daniel Hornburg

    (Seer Inc.)

  • Kelly Blease

    (Element Biosciences)

  • Juan Moreno

    (Element Biosciences)

  • Andrew Boddicker

    (Element Biosciences)

  • Junhua Zhao

    (Element Biosciences)

  • Bryan Lajoie

    (Element Biosciences)

  • Ryan T. Scott

    (NASA Ames Research Center)

  • Rachel R. Gilbert

    (NASA Ames Research Center)

  • San-huei Lai Polo

    (NASA Ames Research Center)

  • Andrew Altomare

    (Element Biosciences)

  • Semyon Kruglyak

    (Element Biosciences)

  • Shawn Levy

    (Element Biosciences)

  • Ishara Ariyapala

    (Alamar Biosciences Inc.)

  • Joanne Beer

    (Alamar Biosciences Inc.)

  • Bingqing Zhang

    (Alamar Biosciences Inc.)

  • Briana M. Hudson

    (NanoString Technologies)

  • Aric Rininger

    (NanoString Technologies)

  • Sarah E. Church

    (NanoString Technologies)

  • Afshin Beheshti

    (NASA Ames Research Center
    Broad Institute of MIT and Harvard)

  • George M. Church

    (Harvard Medical School and the Wyss Institute)

  • Scott M. Smith

    (Biomedical Research and Environmental Sciences Division)

  • Brian E. Crucian

    (Biomedical Research and Environmental Sciences Division)

  • Sara R. Zwart

    (University of Texas Medical Branch)

  • Irina Matei

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • David C. Lyden

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Francine Garrett-Bakelman

    (University of Virginia
    University of Virginia)

  • Jan Krumsiek

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

  • Qiuying Chen

    (Weill Cornell Medicine)

  • Dawson Miller

    (Weill Cornell Medicine)

  • Joe Shuga

    (10x Genomics)

  • Stephen Williams

    (10x Genomics)

  • Corey Nemec

    (10x Genomics)

  • Guy Trudel

    (Ottawa Hospital Research Institute
    The Ottawa Hospital
    University of Ottawa)

  • Martin Pelchat

    (University of Ottawa)

  • Odette Laneuville

    (University of Ottawa)

  • Iwijn De Vlaminck

    (Cornell University)

  • Steven Gross

    (Weill Cornell Medicine)

  • Kelly L. Bolton

    (Washington University School of Medicine)

  • Susan M. Bailey

    (Colorado State University
    Colorado State University)

  • Richard Granstein

    (Weill Cornell Medicine)

  • David Furman

    (Buck Institute for Research on Aging
    Cosmica Biosciences Inc.
    Stanford University
    Universidad Austral and CONICET)

  • Ari M. Melnick

    (Weill Cornell Medicine
    Weill Cornell Medicine)

  • Sylvain V. Costes

    (NASA Ames Research Center)

  • Bader Shirah

    (King Faisal Specialist Hospital and Research Centre)

  • Min Yu

    (University of Southern California)

  • Anil S. Menon

    (University of Texas Medical Branch)

  • Jaime Mateus

    (Space Exploration Technologies Corporation (SpaceX))

  • Cem Meydan

    (Weill Cornell Medicine
    Weill Cornell Medicine
    Weill Cornell Medicine)

  • Christopher E. Mason

    (Weill Cornell Medicine
    Weill Cornell Medicine
    BioAstra Inc.
    The Feil Family Brain and Mind Research Institute)

Abstract

Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1–6. Yet current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools and protocols. Here we present the Space Omics and Medical Atlas (SOMA), an integrated data and sample repository for clinical, cellular and multi-omic research profiles from a diverse range of missions, including the NASA Twins Study7, JAXA CFE study8,9, SpaceX Inspiration4 crew10–12, Axiom and Polaris. The SOMA resource represents a more than tenfold increase in publicly available human space omics data, with matched samples available from the Cornell Aerospace Medicine Biobank. The Atlas includes extensive molecular and physiological profiles encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics and microbiome datasets, which reveal some consistent features across missions, including cytokine shifts, telomere elongation and gene expression changes, as well as mission-specific molecular responses and links to orthologous, tissue-specific mouse datasets. Leveraging the datasets, tools and resources in SOMA can help to accelerate precision aerospace medicine, bringing needed health monitoring, risk mitigation and countermeasure data for upcoming lunar, Mars and exploration-class missions.

Suggested Citation

  • Eliah G. Overbey & JangKeun Kim & Braden T. Tierney & Jiwoon Park & Nadia Houerbi & Alexander G. Lucaci & Sebastian Garcia Medina & Namita Damle & Deena Najjar & Kirill Grigorev & Evan E. Afshin & Kri, 2024. "The Space Omics and Medical Atlas (SOMA) and international astronaut biobank," Nature, Nature, vol. 632(8027), pages 1145-1154, August.
  • Handle: RePEc:nat:nature:v:632:y:2024:i:8027:d:10.1038_s41586-024-07639-y
    DOI: 10.1038/s41586-024-07639-y
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    Cited by:

    1. Lindsay A. Rutter & Matthew J. MacKay & Henry Cope & Nathaniel J. Szewczyk & JangKeun Kim & Eliah Overbey & Braden T. Tierney & Masafumi Muratani & Ben Lamm & Daniela Bezdan & Amber M. Paul & Michael , 2024. "Protective alleles and precision healthcare in crewed spaceflight," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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