IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v1y2010i1d10.1038_ncomms1001.html
   My bibliography  Save this article

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

Author

Listed:
  • Daniel Herranz

    (Tumor Suppression Group, Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.)

  • Maribel Muñoz-Martin

    (Tumor Suppression Group, Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.)

  • Marta Cañamero

    (Comparative Pathology Unit, SpanishNational Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.)

  • Francisca Mulero

    (Molecular Imaging Unit, Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.)

  • Barbara Martinez-Pastor

    (Genomic Instability Group, Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.)

  • Oscar Fernandez-Capetillo

    (Genomic Instability Group, Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.)

  • Manuel Serrano

    (Tumor Suppression Group, Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E-28029, Spain.)

Abstract

Genetic overexpression of protein deacetylase Sir2 increases longevity in a variety of lower organisms, and this has prompted interest in the effects of its closest mammalian homologue, Sirt1, on ageing and cancer. We have generated transgenic mice moderately overexpressing Sirt1 under its own regulatory elements (Sirt1-tg). Old Sirt1-tg mice present lower levels of DNA damage, decreased expression of the ageing-associated gene p16Ink4a, a better general health and fewer spontaneous carcinomas and sarcomas. These effects, however, were not sufficiently potent to affect longevity. To further extend these observations, we developed a metabolic syndrome-associated liver cancer model in which wild-type mice develop multiple carcinomas. Sirt1-tg mice show a reduced susceptibility to liver cancer and exhibit improved hepatic protection from both DNA damage and metabolic damage. Together, these results provide direct proof of the anti-ageing activity of Sirt1 in mammals and of its tumour suppression activity in ageing- and metabolic syndrome-associated cancer.

Suggested Citation

  • Daniel Herranz & Maribel Muñoz-Martin & Marta Cañamero & Francisca Mulero & Barbara Martinez-Pastor & Oscar Fernandez-Capetillo & Manuel Serrano, 2010. "Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer," Nature Communications, Nature, vol. 1(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:1:y:2010:i:1:d:10.1038_ncomms1001
    DOI: 10.1038/ncomms1001
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms1001
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms1001?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Priya Kapoor-Vazirani & Sandip K. Rath & Xu Liu & Zhen Shu & Nicole E. Bowen & Yitong Chen & Ramona Haji-Seyed-Javadi & Waaqo Daddacha & Elizabeth V. Minten & Diana Danelia & Daniela Farchi & Duc M. D, 2022. "SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Lindsay A. Rutter & Matthew J. MacKay & Henry Cope & Nathaniel J. Szewczyk & JangKeun Kim & Eliah Overbey & Braden T. Tierney & Masafumi Muratani & Ben Lamm & Daniela Bezdan & Amber M. Paul & Michael , 2024. "Protective alleles and precision healthcare in crewed spaceflight," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:1:y:2010:i:1:d:10.1038_ncomms1001. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.