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Unravelling the genetic architecture of human complex traits through whole genome sequencing

Author

Listed:
  • Ozvan Bocher

    (Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health)

  • Cristen J. Willer

    (University of Michigan
    University of Michigan
    University of Michigan)

  • Eleftheria Zeggini

    (Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health
    Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine)

Abstract

Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare variation. This Comment highlights the key contributions from this technology and discusses considerations for its use and future perspectives.

Suggested Citation

  • Ozvan Bocher & Cristen J. Willer & Eleftheria Zeggini, 2023. "Unravelling the genetic architecture of human complex traits through whole genome sequencing," Nature Communications, Nature, vol. 14(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39259-x
    DOI: 10.1038/s41467-023-39259-x
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