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Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Author

Listed:
  • Keith Siew

    (University College London)

  • Kevin A. Nestler

    (The George Washington University)

  • Charlotte Nelson

    (University of California San Francisco)

  • Viola D’Ambrosio

    (University College London
    Università Cattolica del Sacro Cuore di Roma)

  • Chutong Zhong

    (University College London)

  • Zhongwang Li

    (University College London
    University College London
    University College London)

  • Alessandra Grillo

    (University College London)

  • Elizabeth R. Wan

    (University College London)

  • Vaksha Patel

    (University College London)

  • Eliah Overbey

    (Weill Cornell Medical College)

  • JangKeun Kim

    (Weill Cornell Medical College)

  • Sanghee Yun

    (University of Pennsylvania Perelman School of Medicine
    Children’s Hospital of Philadelphia)

  • Michael B. Vaughan

    (University College Cork
    Ghent University
    Ghent University)

  • Chris Cheshire

    (The Francis Crick Institute)

  • Laura Cubitt

    (The Francis Crick Institute)

  • Jessica Broni-Tabi

    (University College London)

  • Maneera Yousef Al-Jaber

    (Anti-Doping Laboratory Qatar)

  • Valery Boyko

    (NASA Ames Research Center)

  • Cem Meydan

    (Weill Cornell Medical College)

  • Peter Barker

    (University of Cambridge)

  • Shehbeel Arif

    (Children’s Hospital of Philadelphia
    Children’s Hospital of Philadelphia)

  • Fatemeh Afsari

    (University of Florida)

  • Noah Allen

    (Rensselaer Polytechnic Institute)

  • Mohammed Al-Maadheed

    (Anti-Doping Laboratory Qatar
    University College London)

  • Selin Altinok

    (The University of North Carolina at Chapel Hill)

  • Nourdine Bah

    (The Francis Crick Institute)

  • Samuel Border

    (University of Florida)

  • Amanda L. Brown

    (The University of North Carolina at Chapel Hill)

  • Keith Burling

    (University of Cambridge)

  • Margareth Cheng-Campbell

    (Rensselaer Polytechnic Institute
    Blue Marble Space Institute of Science)

  • Lorianna M. Colón

    (Children’s Hospital of Philadelphia Research Institute)

  • Lovorka Degoricija

    (NASA Ames Research Center)

  • Nichola Figg

    (University of Cambridge)

  • Rebecca Finch

    (Staffordshire University)

  • Jonathan Foox

    (Weill Cornell Medical College
    Weill Cornell Medical College)

  • Pouya Faridi

    (Monash University)

  • Alison French

    (NASA Ames Research Center)

  • Samrawit Gebre

    (NASA Ames Research Center)

  • Peter Gordon

    (University College London)

  • Nadia Houerbi

    (Weill Cornell Medical College)

  • Hossein Valipour Kahrood

    (Monash University
    Monash University)

  • Frederico C. Kiffer

    (Children’s Hospital of Philadelphia)

  • Aleksandra S. Klosinska

    (University of Cambridge)

  • Angela Kubik

    (Rensselaer Polytechnic Institute)

  • Han-Chung Lee

    (Monash University)

  • Yinghui Li

    (China Astronaut Research and Training Center)

  • Nicholas Lucarelli

    (University of Florida)

  • Anthony L. Marullo

    (University College Cork)

  • Irina Matei

    (Cornell University
    Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medical College)

  • Colleen M. McCann

    (The University of North Carolina at Chapel Hill)

  • Sayat Mimar

    (University of Florida)

  • Ahmed Naglah

    (University of Florida)

  • Jérôme Nicod

    (The Francis Crick Institute)

  • Kevin M. O’Shaughnessy

    (University of Cambridge)

  • Lorraine Christine De Oliveira

    (Blue Marble Space Institute of Science
    Federal University of São Paulo (UNIFESP))

  • Leah Oswalt

    (The University of North Carolina at Chapel Hill)

  • Laura Ioana Patras

    (Weill Cornell Medical College)

  • San-huei Lai Polo

    (NASA Ames Research Center)

  • María Rodríguez-Lopez

    (The Francis Crick Institute)

  • Candice Roufosse

    (Imperial College London)

  • Omid Sadeghi-Alavijeh

    (University College London)

  • Rebekah Sanchez-Hodge

    (The University of North Carolina at Chapel Hill)

  • Anindya S. Paul

    (University of Florida)

  • Ralf Bernd Schittenhelm

    (Monash University)

  • Annalise Schweickart

    (Weill Cornell Medical College
    Weill Cornell Medical College)

  • Ryan T. Scott

    (NASA Ames Research Center)

  • Terry Chin Choy Lim Kam Sian

    (Monash University)

  • Willian A. Silveira

    (Staffordshire University
    International Space University)

  • Hubert Slawinski

    (The Francis Crick Institute)

  • Daniel Snell

    (The Francis Crick Institute)

  • Julio Sosa

    (University Health Network)

  • Amanda M. Saravia-Butler

    (NASA Ames Research Center)

  • Marshall Tabetah

    (Purdue University)

  • Erwin Tanuwidjaya

    (Monash University)

  • Simon Walker-Samuel

    (University College London
    University College London)

  • Xiaoping Yang

    (King’s College London)

  • Yasmin

    (University of Cambridge)

  • Haijian Zhang

    (Monash University)

  • Jasminka Godovac-Zimmermann

    (University College London)

  • Pinaki Sarder

    (University of Florida
    University of Florida)

  • Lauren M. Sanders

    (NASA Ames Research Center
    Blue Marble Space Institute of Science)

  • Sylvain V. Costes

    (NASA Ames Research Center)

  • Robert A. A. Campbell

    (University College London)

  • Fathi Karouia

    (Blue Marble Space Institute of Science
    Space Research Within Reach
    Baylor College of Medicine)

  • Vidya Mohamed-Alis

    (Anti-Doping Laboratory Qatar
    University College London)

  • Samuel Rodriques

    (The Francis Crick Institute)

  • Steven Lynham

    (King’s College London)

  • Joel Ricky Steele

    (Monash University)

  • Sergio Baranzini

    (University of California San Francisco)

  • Hossein Fazelinia

    (Children’s Hospital of Philadelphia Research Institute)

  • Zhongquan Dai

    (China Astronaut Research and Training Center)

  • Akira Uruno

    (Tohoku Medical Megabank Organization, Tohoku University, Sendai)

  • Dai Shiba

    (Japan Aerospace Exploration Agency (JAXA)
    Japan Aerospace Exploration Agency (JAXA))

  • Masayuki Yamamoto

    (Tohoku Medical Megabank Organization, Tohoku University, Sendai
    Tohoku University)

  • Eduardo A.C.Almeida

    (NASA Ames Research Center)

  • Elizabeth Blaber

    (Rensselaer Polytechnic Institute
    Rensselaer Polytechnic Institute
    Massachusetts Institute of Technology and Harvard University)

  • Jonathan C. Schisler

    (The University of North Carolina at Chapel Hill)

  • Amelia J. Eisch

    (Children’s Hospital of Philadelphia
    University of Pennsylvania Perelman School of Medicine)

  • Masafumi Muratani

    (University of Tsukuba)

  • Sara R. Zwart

    (University of Texas Medical Branch)

  • Scott M. Smith

    (NASA Johnson Space Center)

  • Jonathan M. Galazka

    (NASA Ames Research Center)

  • Christopher E. Mason

    (Weill Cornell Medical College
    Weill Cornell Medical College
    Weill Cornell Medical College
    Weill Cornell Medical College)

  • Afshin Beheshti

    (NASA Ames Research Center
    Broad Institute
    Universities Space Research Association (USRA))

  • Stephen B. Walsh

    (University College London)

Abstract

Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.

Suggested Citation

  • Keith Siew & Kevin A. Nestler & Charlotte Nelson & Viola D’Ambrosio & Chutong Zhong & Zhongwang Li & Alessandra Grillo & Elizabeth R. Wan & Vaksha Patel & Eliah Overbey & JangKeun Kim & Sanghee Yun & , 2024. "Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49212-1
    DOI: 10.1038/s41467-024-49212-1
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    References listed on IDEAS

    as
    1. Seung Jae Jeong & Shinhye Park & Loi T. Nguyen & Jungwon Hwang & Eun-Young Lee & Hoi-Khoanh Giong & Jeong-Soo Lee & Ina Yoon & Ji-Hyun Lee & Jong Hyun Kim & Hoi Kyoung Kim & Doyeun Kim & Won Suk Yang , 2019. "A threonyl-tRNA synthetase-mediated translation initiation machinery," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
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    3. Blue B. Lake & Rajasree Menon & Seth Winfree & Qiwen Hu & Ricardo Melo Ferreira & Kian Kalhor & Daria Barwinska & Edgar A. Otto & Michael Ferkowicz & Dinh Diep & Nongluk Plongthongkum & Amanda Knoten , 2023. "An atlas of healthy and injured cell states and niches in the human kidney," Nature, Nature, vol. 619(7970), pages 585-594, July.
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