IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-48920-y.html
   My bibliography  Save this article

Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

Author

Listed:
  • J. Tyson McDonald

    (Georgetown University School of Medicine)

  • JangKeun Kim

    (Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine)

  • Lily Farmerie

    (Vascular Medicine Institute at the University of Pittsburgh Department of Medicine
    University of Pittsburgh)

  • Meghan L. Johnson

    (Vascular Medicine Institute at the University of Pittsburgh Department of Medicine)

  • Nidia S. Trovao

    (Fogarty International Center, National Institutes of Health)

  • Shehbeel Arif

    (Children’s Hospital of Philadelphia
    Children’s Hospital of Philadelphia)

  • Keith Siew

    (University College London)

  • Sergey Tsoy

    (Weill Cornell Medicine)

  • Yaron Bram

    (Weill Cornell Medicine)

  • Jiwoon Park

    (Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine)

  • Eliah Overbey

    (Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine)

  • Krista Ryon

    (Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine)

  • Jeffrey Haltom

    (The Children’s Hospital of Philadelphia)

  • Urminder Singh

    (Iowa State University)

  • Francisco J. Enguita

    (Universidade de Lisboa)

  • Victoria Zaksas

    (University of Chicago
    Clever Research Lab)

  • Joseph W. Guarnieri

    (The Children’s Hospital of Philadelphia)

  • Michael Topper

    (The Johns Hopkins Medical Institutions)

  • Douglas C. Wallace

    (The Children’s Hospital of Philadelphia
    University of Pennsylvania School of Medicine)

  • Cem Meydan

    (Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine)

  • Stephen Baylin

    (The Johns Hopkins Medical Institutions)

  • Robert Meller

    (Morehouse School of Medicine)

  • Masafumi Muratani

    (University of Tsukuba
    University of Tsukuba)

  • D. Marshall Porterfield

    (Purdue University)

  • Brett Kaufman

    (Vascular Medicine Institute at the University of Pittsburgh Department of Medicine
    University of Pittsburgh)

  • Marcelo A. Mori

    (Universidade Estadual de Campinas
    Universidade Estadual de Campinas)

  • Stephen B. Walsh

    (University College London)

  • Dominique Sigaudo-Roussel

    (Université Claude Bernard Lyon 1)

  • Saida Mebarek

    (Université Claude Bernard Lyon 1)

  • Massimo Bottini

    (University of Rome Tor Vergata)

  • Christophe A. Marquette

    (Université Claude Bernard Lyon 1)

  • Eve Syrkin Wurtele

    (Iowa State University
    Iowa State University)

  • Robert E. Schwartz

    (Weill Cornell Medicine)

  • Diego Galeano

    (Universidad Nacional de Asunción)

  • Christopher E. Mason

    (Biophysics and Systems Biology and the WorldQuant Initiative, Weill Cornell Medicine)

  • Peter Grabham

    (Columbia University)

  • Afshin Beheshti

    (Broad Institute of MIT and Harvard
    Space Biosciences Division, NASA Ames Research Center)

Abstract

Our previous research revealed a key microRNA signature that is associated with spaceflight that can be used as a biomarker and to develop countermeasure treatments to mitigate the damage caused by space radiation. Here, we expand on this work to determine the biological factors rescued by the countermeasure treatment. We performed RNA-sequencing and transcriptomic analysis on 3D microvessel cell cultures exposed to simulated deep space radiation (0.5 Gy of Galactic Cosmic Radiation) with and without the antagonists to three microRNAs: miR-16-5p, miR-125b-5p, and let-7a-5p (i.e., antagomirs). Significant reduction of inflammation and DNA double strand breaks (DSBs) activity and rescue of mitochondria functions are observed after antagomir treatment. Using data from astronaut participants in the NASA Twin Study, Inspiration4, and JAXA missions, we reveal the genes and pathways implicated in the action of these antagomirs are altered in humans. Our findings indicate a countermeasure strategy that can potentially be utilized by astronauts in spaceflight missions to mitigate space radiation damage.

Suggested Citation

  • J. Tyson McDonald & JangKeun Kim & Lily Farmerie & Meghan L. Johnson & Nidia S. Trovao & Shehbeel Arif & Keith Siew & Sergey Tsoy & Yaron Bram & Jiwoon Park & Eliah Overbey & Krista Ryon & Jeffrey Hal, 2024. "Space radiation damage rescued by inhibition of key spaceflight associated miRNAs," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48920-y
    DOI: 10.1038/s41467-024-48920-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-48920-y
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-48920-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Daehyun Baek & Judit Villén & Chanseok Shin & Fernando D. Camargo & Steven P. Gygi & David P. Bartel, 2008. "The impact of microRNAs on protein output," Nature, Nature, vol. 455(7209), pages 64-71, September.
    2. Anne-Ruxandra Carvunis & Thomas Rolland & Ilan Wapinski & Michael A. Calderwood & Muhammed A. Yildirim & Nicolas Simonis & Benoit Charloteaux & César A. Hidalgo & Justin Barbette & Balaji Santhanam & , 2012. "Proto-genes and de novo gene birth," Nature, Nature, vol. 487(7407), pages 370-374, July.
    3. Victor Ambros, 2004. "The functions of animal microRNAs," Nature, Nature, vol. 431(7006), pages 350-355, September.
    4. Carsten Sticht & Carolina De La Torre & Alisha Parveen & Norbert Gretz, 2018. "miRWalk: An online resource for prediction of microRNA binding sites," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-6, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Junpeng Zhang & Taosheng Xu & Lin Liu & Wu Zhang & Chunwen Zhao & Sijing Li & Jiuyong Li & Nini Rao & Thuc Duy Le, 2020. "LMSM: A modular approach for identifying lncRNA related miRNA sponge modules in breast cancer," PLOS Computational Biology, Public Library of Science, vol. 16(4), pages 1-22, April.
    2. José María Galván-Román & Ángel Lancho-Sánchez & Sergio Luquero-Bueno & Lorena Vega-Piris & Jose Curbelo & Marcos Manzaneque-Pradales & Manuel Gómez & Hortensia de la Fuente & Mara Ortega-Gómez & Javi, 2020. "Usefulness of circulating microRNAs miR-146a and miR-16-5p as prognostic biomarkers in community-acquired pneumonia," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-13, October.
    3. Kshitij Srivastava & Anvesha Srivastava, 2012. "Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-1, November.
    4. Yanyan Wang & Yujie Zhang & Chi Pan & Feixia Ma & Suzhan Zhang, 2015. "Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-13, February.
    5. Rujia Chen & Ning Xiao & Yue Lu & Tianyun Tao & Qianfeng Huang & Shuting Wang & Zhichao Wang & Mingli Chuan & Qing Bu & Zhou Lu & Hanyao Wang & Yanze Su & Yi Ji & Jianheng Ding & Ahmed Gharib & Huixin, 2023. "A de novo evolved gene contributes to rice grain shape difference between indica and japonica," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Charlotte Glinge & Sebastian Clauss & Kim Boddum & Reza Jabbari & Javad Jabbari & Bjarke Risgaard & Philipp Tomsits & Bianca Hildebrand & Stefan Kääb & Reza Wakili & Thomas Jespersen & Jacob Tfelt-Han, 2017. "Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-16, February.
    7. Hossain Ahmed & Beyene Joseph, 2013. "Estimation of weighted log partial area under the ROC curve and its application to MicroRNA expression data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 12(6), pages 743-755, December.
    8. Hai Lian & Lei Wang & Jingmin Zhang, 2012. "Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-7, February.
    9. Léa Maitre & Mariona Bustamante & Carles Hernández-Ferrer & Denise Thiel & Chung-Ho E. Lau & Alexandros P. Siskos & Marta Vives-Usano & Carlos Ruiz-Arenas & Dolors Pelegrí-Sisó & Oliver Robinson & Dan, 2022. "Multi-omics signatures of the human early life exposome," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    10. Le Thi Truc Linh, 2018. "The Microrna 29 family and its regulation," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 18-27.
    11. Seyedehsadaf Asfa & Halil Ibrahim Toy & Reza Arshinchi Bonab & George P. Chrousos & Athanasia Pavlopoulou & Styliani A. Geronikolou, 2023. "Soft Tissue Ewing Sarcoma Cell Drug Resistance Revisited: A Systems Biology Approach," IJERPH, MDPI, vol. 20(13), pages 1-17, July.
    12. Pedro Patraquim & Emile G. Magny & José I. Pueyo & Ana Isabel Platero & Juan Pablo Couso, 2022. "Translation and natural selection of micropeptides from long non-canonical RNAs," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    13. Li Li & Yunjian Sheng & Lin Lv & Jian Gao, 2013. "The Association between Two MicroRNA Variants (miR-499, miR-149) and Gastrointestinal Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    14. Blanca Elena Castro-Magdonel & Manuela Orjuela & Diana E Alvarez-Suarez & Javier Camacho & Lourdes Cabrera-Muñoz & Stanislaw Sadowinski-Pine & Aurora Medina-Sanson & Citlali Lara-Molina & Daphne Garcí, 2020. "Circulating miRNome detection analysis reveals 537 miRNAS in plasma, 625 in extracellular vesicles and a discriminant plasma signature of 19 miRNAs in children with retinoblastoma from which 14 are al," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-19, April.
    15. Adam Emmer, 2019. "The careers behind and the impact of solo author articles in Nature and Science," Scientometrics, Springer;Akadémiai Kiadó, vol. 120(2), pages 825-840, August.
    16. Hisakazu Iwama & Kiyohito Kato & Hitomi Imachi & Koji Murao & Tsutomu Masaki, 2018. "Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-20, May.
    17. Soumita Seth & Saurav Mallik & Atikul Islam & Tapas Bhadra & Arup Roy & Pawan Kumar Singh & Aimin Li & Zhongming Zhao, 2023. "Identifying Genetic Signatures from Single-Cell RNA Sequencing Data by Matrix Imputation and Reduced Set Gene Clustering," Mathematics, MDPI, vol. 11(20), pages 1-26, October.
    18. Ray M Marín & Jiří Vaníček, 2012. "Optimal Use of Conservation and Accessibility Filters in MicroRNA Target Prediction," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-11, February.
    19. Junhui Peng & Li Zhao, 2024. "The origin and structural evolution of de novo genes in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    20. Hongbo Shi & Guangde Zhang & Meng Zhou & Liang Cheng & Haixiu Yang & Jing Wang & Jie Sun & Zhenzhen Wang, 2016. "Integration of Multiple Genomic and Phenotype Data to Infer Novel miRNA-Disease Associations," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-15, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48920-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.