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Proto-genes and de novo gene birth

Author

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  • Anne-Ruxandra Carvunis

    (Dana-Farber Cancer Institute
    Harvard Medical School
    UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Computational and Mathematical Biology Group, Grenoble F-38041, France)

  • Thomas Rolland

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Ilan Wapinski

    (Harvard Medical School)

  • Michael A. Calderwood

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Muhammed A. Yildirim

    (Center for International Development and Harvard University)

  • Nicolas Simonis

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Present address: Laboratoire de Bioinformatique des Génomes et des Réseaux (BiGRe), Campus Plaine, Free University of Brussels, 1050 Brussels, Wallonia-Brussels Federation, Belgium.)

  • Benoit Charloteaux

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liege, 4000 Liege, Wallonia-Brussels Federation, Belgium)

  • César A. Hidalgo

    (The MIT Media Lab, Massachusetts Institute of Technology)

  • Justin Barbette

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Balaji Santhanam

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Gloria A. Brar

    (Howard Hughes Medical Institute, University of California, San Francisco, and California Institute for Quantitative Biosciences)

  • Jonathan S. Weissman

    (Howard Hughes Medical Institute, University of California, San Francisco, and California Institute for Quantitative Biosciences)

  • Aviv Regev

    (Broad Institute of MIT and Harvard
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

  • Nicolas Thierry-Mieg

    (UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Computational and Mathematical Biology Group, Grenoble F-38041, France)

  • Michael E. Cusick

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Marc Vidal

    (Dana-Farber Cancer Institute
    Harvard Medical School)

Abstract

Novel protein-coding genes can arise either from pre-existing genes or de novo; here it is shown that functional genes emerge de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.

Suggested Citation

  • Anne-Ruxandra Carvunis & Thomas Rolland & Ilan Wapinski & Michael A. Calderwood & Muhammed A. Yildirim & Nicolas Simonis & Benoit Charloteaux & César A. Hidalgo & Justin Barbette & Balaji Santhanam & , 2012. "Proto-genes and de novo gene birth," Nature, Nature, vol. 487(7407), pages 370-374, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7407:d:10.1038_nature11184
    DOI: 10.1038/nature11184
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    Citations

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    Cited by:

    1. Rujia Chen & Ning Xiao & Yue Lu & Tianyun Tao & Qianfeng Huang & Shuting Wang & Zhichao Wang & Mingli Chuan & Qing Bu & Zhou Lu & Hanyao Wang & Yanze Su & Yi Ji & Jianheng Ding & Ahmed Gharib & Huixin, 2023. "A de novo evolved gene contributes to rice grain shape difference between indica and japonica," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Eduardo Vieira de Souza & Angie L. Bookout & Christopher A. Barnes & Brendan Miller & Pablo Machado & Luiz A. Basso & Cristiano V. Bizarro & Alan Saghatelian, 2024. "Rp3: Ribosome profiling-assisted proteogenomics improves coverage and confidence during microprotein discovery," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. J. Tyson McDonald & JangKeun Kim & Lily Farmerie & Meghan L. Johnson & Nidia S. Trovao & Shehbeel Arif & Keith Siew & Sergey Tsoy & Yaron Bram & Jiwoon Park & Eliah Overbey & Krista Ryon & Jeffrey Hal, 2024. "Space radiation damage rescued by inhibition of key spaceflight associated miRNAs," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    4. Pedro Patraquim & Emile G. Magny & José I. Pueyo & Ana Isabel Platero & Juan Pablo Couso, 2022. "Translation and natural selection of micropeptides from long non-canonical RNAs," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Junhui Peng & Li Zhao, 2024. "The origin and structural evolution of de novo genes in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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