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Long-term relapse-free survival enabled by integrating targeted antibacteria in antitumor treatment

Author

Listed:
  • Yuanlin Wang

    (Harbin Institute of Technology)

  • Yaqian Han

    (Harbin Institute of Technology)

  • Chenhui Yang

    (Harbin Institute of Technology)

  • Tiancheng Bai

    (Harbin Institute of Technology)

  • Chenggang Zhang

    (Harbin Institute of Technology)

  • Zhaotong Wang

    (Harbin Institute of Technology)

  • Ye Sun

    (Harbin Institute of Technology)

  • Ying Hu

    (Harbin Institute of Technology)

  • Flemming Besenbacher

    (Aarhus University)

  • Chunying Chen

    (Chinese Academy of Sciences)

  • Miao Yu

    (Harbin Institute of Technology)

Abstract

The role of tumor-resident intracellular microbiota (TRIM) in carcinogenesis has sparked enormous interest. Nevertheless, the impact of TRIM-targeted antibacteria on tumor inhibition and immune regulation in the tumor microenvironment (TME) remains unexplored. Herein, we report long-term relapse-free survival by coordinating antibacteria with antitumor treatment, addressing the aggravated immunosuppression and tumor overgrowth induced by TRIM using breast and prostate cancer models. Combining Ag+ release with a Fenton-like reaction and photothermal conversion, simultaneous bacteria killing and multimodal antitumor therapy are enabled by a single agent. Free of immune-stimulating drugs, the agent restores antitumor immune surveillance and activates immunological responses. Secondary inoculation and distal tumor analysis confirm lasting immunological memory and systemic immune responses. A relapse-free survival of >700 days is achieved. This work unravels the crucial role of TRIM-targeted antibacteria in tumor inhibition and unlocks an unconventional route for immune regulation in TME and a complete cure for cancer.

Suggested Citation

  • Yuanlin Wang & Yaqian Han & Chenhui Yang & Tiancheng Bai & Chenggang Zhang & Zhaotong Wang & Ye Sun & Ying Hu & Flemming Besenbacher & Chunying Chen & Miao Yu, 2024. "Long-term relapse-free survival enabled by integrating targeted antibacteria in antitumor treatment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48662-x
    DOI: 10.1038/s41467-024-48662-x
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    1. Jason Lloyd-Price & Anup Mahurkar & Gholamali Rahnavard & Jonathan Crabtree & Joshua Orvis & A. Brantley Hall & Arthur Brady & Heather H. Creasy & Carrie McCracken & Michelle G. Giglio & Daniel McDona, 2017. "Erratum: Strains, functions and dynamics in the expanded Human Microbiome Project," Nature, Nature, vol. 551(7679), pages 256-256, November.
    2. Xing Qin & Chu Wu & Dechao Niu & Limei Qin & Xia Wang & Qigang Wang & Yongsheng Li, 2021. "Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Degao Chen & Jing Xie & Roland Fiskesund & Wenqian Dong & Xiaoyu Liang & Jiadi Lv & Xun Jin & Jinyan Liu & Siqi Mo & Tianzhen Zhang & Feiran Cheng & Yabo Zhou & Huafeng Zhang & Ke Tang & Jingwei Ma & , 2018. "Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    4. Hui Zhou & Xiaodong Zeng & Anguo Li & Wenyi Zhou & Lin Tang & Wenbo Hu & Quli Fan & Xianli Meng & Hai Deng & Lian Duan & Yanqin Li & Zixin Deng & Xuechuan Hong & Yuling Xiao, 2020. "Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    5. Jason Lloyd-Price & Anup Mahurkar & Gholamali Rahnavard & Jonathan Crabtree & Joshua Orvis & A. Brantley Hall & Arthur Brady & Heather H. Creasy & Carrie McCracken & Michelle G. Giglio & Daniel McDona, 2017. "Strains, functions and dynamics in the expanded Human Microbiome Project," Nature, Nature, vol. 550(7674), pages 61-66, October.
    6. Tianqun Lang & Runqi Zhu & Xiao Zhu & Wenlu Yan & Yu Li & Yihui Zhai & Ting Wu & Xin Huang & Qi Yin & Yaping Li, 2023. "Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Degao Chen & Jing Xie & Roland Fiskesund & Wenqian Dong & Xiaoyu Liang & Jiadi Lv & Xun Jin & Jinyan Liu & Siqi Mo & Tianzhen Zhang & Feiran Cheng & Yabo Zhou & Huafeng Zhang & Ke Tang & Jingwei Ma & , 2018. "Publisher Correction: Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype," Nature Communications, Nature, vol. 9(1), pages 1-1, December.
    8. Xiujuan Wu & Peng Tang & Shifei Li & Shushu Wang & Yueyang Liang & Ling Zhong & Lin Ren & Ting Zhang & Yi Zhang, 2018. "A randomized and open-label phase II trial reports the efficacy of neoadjuvant lobaplatin in breast cancer," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
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