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Long-term relapse-free survival enabled by integrating targeted antibacteria in antitumor treatment

Author

Listed:
  • Yuanlin Wang

    (Harbin Institute of Technology)

  • Yaqian Han

    (Harbin Institute of Technology)

  • Chenhui Yang

    (Harbin Institute of Technology)

  • Tiancheng Bai

    (Harbin Institute of Technology)

  • Chenggang Zhang

    (Harbin Institute of Technology)

  • Zhaotong Wang

    (Harbin Institute of Technology)

  • Ye Sun

    (Harbin Institute of Technology)

  • Ying Hu

    (Harbin Institute of Technology)

  • Flemming Besenbacher

    (Aarhus University)

  • Chunying Chen

    (Chinese Academy of Sciences)

  • Miao Yu

    (Harbin Institute of Technology)

Abstract

The role of tumor-resident intracellular microbiota (TRIM) in carcinogenesis has sparked enormous interest. Nevertheless, the impact of TRIM-targeted antibacteria on tumor inhibition and immune regulation in the tumor microenvironment (TME) remains unexplored. Herein, we report long-term relapse-free survival by coordinating antibacteria with antitumor treatment, addressing the aggravated immunosuppression and tumor overgrowth induced by TRIM using breast and prostate cancer models. Combining Ag+ release with a Fenton-like reaction and photothermal conversion, simultaneous bacteria killing and multimodal antitumor therapy are enabled by a single agent. Free of immune-stimulating drugs, the agent restores antitumor immune surveillance and activates immunological responses. Secondary inoculation and distal tumor analysis confirm lasting immunological memory and systemic immune responses. A relapse-free survival of >700 days is achieved. This work unravels the crucial role of TRIM-targeted antibacteria in tumor inhibition and unlocks an unconventional route for immune regulation in TME and a complete cure for cancer.

Suggested Citation

  • Yuanlin Wang & Yaqian Han & Chenhui Yang & Tiancheng Bai & Chenggang Zhang & Zhaotong Wang & Ye Sun & Ying Hu & Flemming Besenbacher & Chunying Chen & Miao Yu, 2024. "Long-term relapse-free survival enabled by integrating targeted antibacteria in antitumor treatment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48662-x
    DOI: 10.1038/s41467-024-48662-x
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