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Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy

Author

Listed:
  • Hui Zhou

    (Wuhan University School of Pharmaceutical Sciences
    Tibet University)

  • Xiaodong Zeng

    (Wuhan University School of Pharmaceutical Sciences
    Shenzhen Institute of Wuhan University)

  • Anguo Li

    (Wuhan University School of Pharmaceutical Sciences)

  • Wenyi Zhou

    (Wuhan University School of Pharmaceutical Sciences
    Shenzhen Institute of Wuhan University)

  • Lin Tang

    (Wuhan University School of Pharmaceutical Sciences)

  • Wenbo Hu

    (Nanjing University of Posts and Telecommunications)

  • Quli Fan

    (Nanjing University of Posts and Telecommunications)

  • Xianli Meng

    (Chengdu University of Traditional Chinese Medicine, Wenjiang)

  • Hai Deng

    (University of Aberdeen)

  • Lian Duan

    (Wuhan University School of Pharmaceutical Sciences)

  • Yanqin Li

    (Wuhan University School of Pharmaceutical Sciences)

  • Zixin Deng

    (Wuhan University School of Pharmaceutical Sciences)

  • Xuechuan Hong

    (Wuhan University School of Pharmaceutical Sciences
    Tibet University)

  • Yuling Xiao

    (Wuhan University School of Pharmaceutical Sciences
    Shenzhen Institute of Wuhan University)

Abstract

NIR-II fluorophores have shown great promise for biomedical applications with superior in vivo optical properties. To date, few small-molecule NIR-II fluorophores have been discovered with donor-acceptor-donor (D-A-D) or symmetrical structures, and upconversion-mitochondria-targeted NIR-II dyes have not been reported. Herein, we report development of D-A type thiopyrylium-based NIR-II fluorophores with frequency upconversion luminescence (FUCL) at ~580 nm upon excitation at ~850 nm. H4-PEG-PT can not only quickly and effectively image mitochondria in live or fixed osteosarcoma cells with subcellular resolution at 1 nM, but also efficiently convert optical energy into heat, achieving mitochondria-targeted photothermal cancer therapy without ROS effects. H4-PEG-PT has been further evaluated in vivo and exhibited strong tumor uptake, specific NIR-II signals with high spatial and temporal resolution, and remarkable NIR-II image-guided photothermal therapy. This report presents the first D-A type thiopyrylium NIR-II theranostics for synchronous upconversion-mitochondria-targeted cell imaging, in vivo NIR-II osteosarcoma imaging and excellent photothermal efficiency.

Suggested Citation

  • Hui Zhou & Xiaodong Zeng & Anguo Li & Wenyi Zhou & Lin Tang & Wenbo Hu & Quli Fan & Xianli Meng & Hai Deng & Lian Duan & Yanqin Li & Zixin Deng & Xuechuan Hong & Yuling Xiao, 2020. "Upconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-19945-w
    DOI: 10.1038/s41467-020-19945-w
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    Cited by:

    1. Yuanlin Wang & Yaqian Han & Chenhui Yang & Tiancheng Bai & Chenggang Zhang & Zhaotong Wang & Ye Sun & Ying Hu & Flemming Besenbacher & Chunying Chen & Miao Yu, 2024. "Long-term relapse-free survival enabled by integrating targeted antibacteria in antitumor treatment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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