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Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data

Author

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  • Soo Hwan Byun

    (Department of Oral & Maxillofacial Surgery, Dentistry, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea
    Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon 24252, Korea)

  • Sunki Lee

    (Division of Cardiology, Department of Internal Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Dongtan 18450, Korea)

  • Sung Hun Kang

    (Department of Biomedical Sciences, College of Medicine, Hallym University, Chuncheon 24252, Korea)

  • Hyo Geun Choi

    (Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon 24252, Korea
    Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
    Department of Otorhinolaryngology-Head & Neck Surgery, Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea)

  • Seok Jin Hong

    (Research Center of Clinical Dentistry, Hallym University Clinical Dentistry Graduate School, Chuncheon 24252, Korea
    Department of Otorhinolaryngology-Head & Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Dongtan 18450, Korea)

Abstract

This cross-sectional study aimed to evaluate the association between periodontitis and cardiovascular disease (CVD) by reviewing and discussing the role of the oral microbiome in periodontitis and CVD. This prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study from 2004 to 2016. We selected 9973 patients with periodontitis and 125,304 controls (non-periodontitis) from 173,209 participants and analyzed their medical histories to determine the relationship between cerebral stroke/ischemic heart disease and periodontitis. The participants were questioned about any previous history of hypertension, diabetes mellitus, hyperlipidemia, cerebral stroke (hemorrhagic or ischemic), ischemic heart disease (angina or myocardial infarction), and periodontitis. Their body mass index, smoking habit, alcohol intake, nutritional intake, and income were recorded. The Chi-square test, independent t -test, and two-tailed analyses were used for statistical analysis. The adjusted OR (aOR) of periodontitis for stroke was 1.35 (95% confidence interval (CI) = 1.16–1.57, p < 0.001). The aOR of periodontitis for ischemic heart disease was 1.34 (95% CI = 1.22–1.48, p < 0.001). We concluded that periodontitis was associated with CVD and may be a risk factor for CVD. However, further studies are required to determine the association between periodontal treatment and CVD.

Suggested Citation

  • Soo Hwan Byun & Sunki Lee & Sung Hun Kang & Hyo Geun Choi & Seok Jin Hong, 2020. "Cross-Sectional Analysis of the Association between Periodontitis and Cardiovascular Disease Using the Korean Genome and Epidemiology Study Data," IJERPH, MDPI, vol. 17(14), pages 1-12, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:14:p:5237-:d:387117
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    References listed on IDEAS

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    1. Jason Lloyd-Price & Anup Mahurkar & Gholamali Rahnavard & Jonathan Crabtree & Joshua Orvis & A. Brantley Hall & Arthur Brady & Heather H. Creasy & Carrie McCracken & Michelle G. Giglio & Daniel McDona, 2017. "Strains, functions and dynamics in the expanded Human Microbiome Project," Nature, Nature, vol. 550(7674), pages 61-66, October.
    2. Jason Lloyd-Price & Anup Mahurkar & Gholamali Rahnavard & Jonathan Crabtree & Joshua Orvis & A. Brantley Hall & Arthur Brady & Heather H. Creasy & Carrie McCracken & Michelle G. Giglio & Daniel McDona, 2017. "Erratum: Strains, functions and dynamics in the expanded Human Microbiome Project," Nature, Nature, vol. 551(7679), pages 256-256, November.
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    1. Masanobu Abe & Ai Ohsato & Yuko Fujihara & Kazuto Hoshi & Shintaro Yanagimoto, 2023. "A Comparative Study of Periodontal Health Status between International and Domestic University Students in Japan," IJERPH, MDPI, vol. 20(5), pages 1-10, February.
    2. Masanobu Abe & Akihisa Mitani & Atsushi Yao & Liang Zong & Chun-Dong Zhang & Kazuto Hoshi & Shintaro Yanagimoto, 2022. "Oral Health in Japan: State-of-the-Art and Perspectives," IJERPH, MDPI, vol. 19(14), pages 1-4, July.

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