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Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network

Author

Listed:
  • Satoko Amemori

    (Kyoto University
    Japan Society for the Promotion of Science)

  • Ann M. Graybiel

    (Massachusetts Institute of Technology)

  • Ken-ichi Amemori

    (Kyoto University)

Abstract

The dorsolateral prefrontal cortex (dlPFC) is crucial for regulation of emotion that is known to aid prevention of depression. The broader fronto-cingulo-striatal (FCS) network, including cognitive dlPFC and limbic cingulo-striatal regions, has been associated with a negative evaluation bias often seen in depression. The mechanism by which dlPFC regulates the limbic system remains largely unclear. Here we have successfully induced a negative bias in decision-making in female primates performing a conflict decision-making task, by directly microstimulating the subgenual cingulate cortex while simultaneously recording FCS local field potentials (LFPs). The artificially induced negative bias in decision-making was associated with a significant decrease in functional connectivity from cognitive to limbic FCS regions, represented by a reduction in Granger causality in beta-range LFPs from the dlPFC to the other regions. The loss of top-down directional influence from cognitive to limbic regions, we suggest, could underlie negative biases in decision-making as observed in depressive states.

Suggested Citation

  • Satoko Amemori & Ann M. Graybiel & Ken-ichi Amemori, 2024. "Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48375-1
    DOI: 10.1038/s41467-024-48375-1
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    References listed on IDEAS

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    1. Hamed Nili & Cai Wingfield & Alexander Walther & Li Su & William Marslen-Wilson & Nikolaus Kriegeskorte, 2014. "A Toolbox for Representational Similarity Analysis," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-11, April.
    2. Laith Alexander & Christian M. Wood & Philip L. R. Gaskin & Stephen J. Sawiak & Tim D. Fryer & Young T. Hong & Lauren McIver & Hannah F. Clarke & Angela C. Roberts, 2020. "Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
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