IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-47698-3.html
   My bibliography  Save this article

CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators

Author

Listed:
  • Hao-Ching Jiang

    (University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School)

  • Sung Jin Park

    (University of Massachusetts Chan Medical School)

  • I-Hao Wang

    (University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School)

  • Daniel M. Bear

    (Harvard Medical School
    Stanford University)

  • Alexandra Nowlan

    (Harvard Medical School
    University of North Carolina School of Medicine)

  • Paul L. Greer

    (University of Massachusetts Chan Medical School)

Abstract

The mammalian olfactory system detects and discriminates between millions of odorants to elicit appropriate behavioral responses. While much has been learned about how olfactory sensory neurons detect odorants and signal their presence, how specific innate, unlearned behaviors are initiated in response to ethologically relevant odors remains poorly understood. Here, we show that the 4-transmembrane protein CD20, also known as MS4A1, is expressed in a previously uncharacterized subpopulation of olfactory sensory neurons in the main olfactory epithelium of the murine nasal cavity and functions as a mammalian olfactory receptor that recognizes compounds produced by mouse predators. While wildtype mice avoid these predator odorants, mice genetically deleted of CD20 do not appropriately respond. Together, this work reveals a CD20-mediated odor-sensing mechanism in the mammalian olfactory system that triggers innate behaviors critical for organismal survival.

Suggested Citation

  • Hao-Ching Jiang & Sung Jin Park & I-Hao Wang & Daniel M. Bear & Alexandra Nowlan & Paul L. Greer, 2024. "CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47698-3
    DOI: 10.1038/s41467-024-47698-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-47698-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-47698-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Stuart Firestein, 2001. "How the olfactory system makes sense of scents," Nature, Nature, vol. 413(6852), pages 211-218, September.
    2. Peter A. Brennan & Frank Zufall, 2006. "Pheromonal communication in vertebrates," Nature, Nature, vol. 444(7117), pages 308-315, November.
    3. Stephen D. Liberles & Linda B. Buck, 2006. "A second class of chemosensory receptors in the olfactory epithelium," Nature, Nature, vol. 442(7103), pages 645-650, August.
    4. Cornelia I. Bargmann, 2006. "Comparative chemosensation from receptors to ecology," Nature, Nature, vol. 444(7117), pages 295-301, November.
    5. Adam Dewan & Rodrigo Pacifico & Ross Zhan & Dmitry Rinberg & Thomas Bozza, 2013. "Non-redundant coding of aversive odours in the main olfactory pathway," Nature, Nature, vol. 497(7450), pages 486-489, May.
    6. Stéphane Rivière & Ludivine Challet & Daniela Fluegge & Marc Spehr & Ivan Rodriguez, 2009. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors," Nature, Nature, vol. 459(7246), pages 574-577, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Anastasiia Gusach & Yang Lee & Armin Nikpour Khoshgrudi & Elizaveta Mukhaleva & Ning Ma & Eline J. Koers & Qingchao Chen & Patricia C. Edwards & Fanglu Huang & Jonathan Kim & Filippo Mancia & Dmitry B, 2024. "Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Arunkumar Krishnan & Markus Sällman Almén & Robert Fredriksson & Helgi B Schiöth, 2014. "Insights into the Origin of Nematode Chemosensory GPCRs: Putative Orthologs of the Srw Family Are Found across Several Phyla of Protostomes," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-12, March.
    3. Jann F Kolter & Markus F Hildenbrand & Sandy Popp & Stephan Nauroth & Julian Bankmann & Lisa Rother & Jonas Waider & Jürgen Deckert & Esther Asan & Peter M Jakob & Klaus-Peter Lesch & Angelika Schmitt, 2021. "Serotonin transporter genotype modulates resting state and predator stress-induced amygdala perfusion in mice in a sex-dependent manner," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-22, February.
    4. Gregory Zilberg & Alexandra K. Parpounas & Audrey L. Warren & Shifan Yang & Daniel Wacker, 2024. "Molecular basis of human trace amine-associated receptor 1 activation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Agnes, Everton J. & Erichsen, Rubem & Brunnet, Leonardo G., 2012. "Model architecture for associative memory in a neural network of spiking neurons," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 391(3), pages 843-848.
    6. Maxime Policarpo & Maude W. Baldwin & Didier Casane & Walter Salzburger, 2024. "Diversity and evolution of the vertebrate chemoreceptor gene repertoire," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Jane S. Huang & Tenzin Kunkhyen & Alexander N. Rangel & Taryn R. Brechbill & Jordan D. Gregory & Emily D. Winson-Bushby & Beichen Liu & Jonathan T. Avon & Ryan J. Muggleton & Claire E. J. Cheetham, 2022. "Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    8. Marylène Rugard & Thomas Jaylet & Olivier Taboureau & Anne Tromelin & Karine Audouze, 2021. "Smell compounds classification using UMAP to increase knowledge of odors and molecular structures linkages," PLOS ONE, Public Library of Science, vol. 16(5), pages 1-17, May.
    9. Silva, Joaquim & Sá, Elisabete Sampaio & Escadas, Marco & Carvalho, Joana, 2021. "The influence of ambient scent on the passengers’ experience, emotions and behavioral intentions: An experimental study in a Public Bus service," Transport Policy, Elsevier, vol. 106(C), pages 88-98.
    10. Jason B Castro & Arvind Ramanathan & Chakra S Chennubhotla, 2013. "Categorical Dimensions of Human Odor Descriptor Space Revealed by Non-Negative Matrix Factorization," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-16, September.
    11. Chulwon Choi & Jungnam Bae & Seonghan Kim & Seho Lee & Hyunook Kang & Jinuk Kim & Injin Bang & Kiheon Kim & Won-Ki Huh & Chaok Seok & Hahnbeom Park & Wonpil Im & Hee-Jung Choi, 2023. "Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47698-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.