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CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators

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Listed:
  • Hao-Ching Jiang

    (University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School)

  • Sung Jin Park

    (University of Massachusetts Chan Medical School)

  • I-Hao Wang

    (University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School
    University of Massachusetts Chan Medical School)

  • Daniel M. Bear

    (Harvard Medical School
    Stanford University)

  • Alexandra Nowlan

    (Harvard Medical School
    University of North Carolina School of Medicine)

  • Paul L. Greer

    (University of Massachusetts Chan Medical School)

Abstract

The mammalian olfactory system detects and discriminates between millions of odorants to elicit appropriate behavioral responses. While much has been learned about how olfactory sensory neurons detect odorants and signal their presence, how specific innate, unlearned behaviors are initiated in response to ethologically relevant odors remains poorly understood. Here, we show that the 4-transmembrane protein CD20, also known as MS4A1, is expressed in a previously uncharacterized subpopulation of olfactory sensory neurons in the main olfactory epithelium of the murine nasal cavity and functions as a mammalian olfactory receptor that recognizes compounds produced by mouse predators. While wildtype mice avoid these predator odorants, mice genetically deleted of CD20 do not appropriately respond. Together, this work reveals a CD20-mediated odor-sensing mechanism in the mammalian olfactory system that triggers innate behaviors critical for organismal survival.

Suggested Citation

  • Hao-Ching Jiang & Sung Jin Park & I-Hao Wang & Daniel M. Bear & Alexandra Nowlan & Paul L. Greer, 2024. "CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47698-3
    DOI: 10.1038/s41467-024-47698-3
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    References listed on IDEAS

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