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Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

Author

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  • Stéphane Rivière

    (and National Center of Competence ‘Frontiers in Genetics’, University of Geneva)

  • Ludivine Challet

    (and National Center of Competence ‘Frontiers in Genetics’, University of Geneva)

  • Daniela Fluegge

    (Ruhr University
    Present address: Department of Chemosensation, Institute of Biology II, RWTH Aachen University, 52074 Aachen, Germany.)

  • Marc Spehr

    (Ruhr University
    Present address: Department of Chemosensation, Institute of Biology II, RWTH Aachen University, 52074 Aachen, Germany.)

  • Ivan Rodriguez

    (and National Center of Competence ‘Frontiers in Genetics’, University of Geneva)

Abstract

A new chemosensor family To date, four types of olfactory receptors have been described in mammals — odorant receptors, trace amine-associated receptors and vomeronasal type 1 and type 2 receptor superfamilies. Rivière et al. now report the identification of a additional novel olfactory receptor family, expressed by mouse vomeronasal sensory neurons. This family is encoded by five members of the formyl peptide receptor-related gene family (FPRs), which are otherwise known to mediate immune cell response to infection Cells expressing FPRs respond to ligands associated with disease and inflammation, which are excreted in urine, raising the possibility that FPRs detect the health status of individuals.

Suggested Citation

  • Stéphane Rivière & Ludivine Challet & Daniela Fluegge & Marc Spehr & Ivan Rodriguez, 2009. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors," Nature, Nature, vol. 459(7246), pages 574-577, May.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7246:d:10.1038_nature08029
    DOI: 10.1038/nature08029
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    Cited by:

    1. Hao-Ching Jiang & Sung Jin Park & I-Hao Wang & Daniel M. Bear & Alexandra Nowlan & Paul L. Greer, 2024. "CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset of olfactory sensory neurons that mediates innate avoidance of predators," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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